Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism

Fig. 3

MetS-serum promotes inflammation, catabolism, and FAO in nMetS-KOA-FLS.. MetS-KOA serum (5%) was used to stimulate nMetS-KOA-FLS for 24 h (5% FBS was used as control). (Ctrl: 5% FBS, Serum: 5% serum of MetS-KOA, n = 5.) a, mRNA levels of CCL3, ICAM1, TNFα, MMP13 and ADAMTS4 relative to control. b, CPT1A transcription levels in nMetS-KOA-FLS after treatment with 5% serum from MetS-KOA. c, Protein level of CPT1A in nMetS-KOA-FLS after treatment with 5% serum from MetS-KOA. d, mRNA levels of HK2 and LDHA relative to control. e, Protein levels of HK2 and LDHA in nMetS-KOA-FLS after treatment with 5% serum from MetS-KOA. Data are expressed as means ± s.e.m. Statistical significance indicated as *P < 0.05, **P < 0.01, and ***P < 0.001, as assessed by matched samples t- test

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us