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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism

Fig. 8

Resistin regulates inflammation and catabolism by promoting FAO of MetS-KOA-FLS via CAP1/PKA/CREB. Resistin binds to CAP1 to activate PKA, which in turn phosphorylates CREB-Ser (133). Phosphorylation of CREB-Ser (133) increases its transcriptional activity and promotes the transcription of CPT1A. Increased expression of CPT1A can promote the transport of free fatty acids to mitochondria, which may increase cellular FAO. This upregulation of FAO in MetS-KOA-FLS further promotes inflammation and catabolism

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Arthritis Research & Therapy

ISSN: 1478-6362

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