Fig. 1

Patient disposition
Note: Some patients may have discontinued the study treatment but remained in the study and completed the 6- or 12-month follow-up for baseline and safety assessments. Premature discontinuation refers to patients who discontinued the study before the specified timepoint
AE adverse event, DAS28(CRP) disease activity score in 28 joints using C-reactive protein, D/C discontinuation, FAS full analysis set, f/u follow-up, LOE lack of efficacy, mFAS modified FAS