Table 2 ISGs and cytokine/chemokine levels in IIM patients across MSA groups

IFIT1

1.0 (0.6, 1.7)

2.0 (1.2, 3.0)

0.7 (0.2, 2.0)

MDA5 (+) vs. ARS (+), P < 0.05

IFI44

0.7 (0.4, 1.0)

1.3 (0.6, 3.0)

0.7 (0.1, 1.0)

MDA5 (+) vs. ARS (+), P < 0.05

RSAD2

1.2 (0.7, 1.8)

2.1 (1.1, 2.9)

0.7 (0.5, 2.1)

MDA5 (+) vs. ARS (+), P < 0.05

MX1

4.3 (1.1, 12.0)

1.3 (0.5, 6.7)

0.5 (0.1, 5.7)

ISG15

2.2 (0.6, 10.5)

1.2 (0.9, 5.4)

1.0 (0.3, 2.8)

SIGLEC1

1.6 (1.1, 2.9)

2.0 (1.3, 3.8)

0.3 (0.2, 1.8)

ARS (+) vs. MSA(-), P<0.05

IFI44L

1.0 (0.4, 1.2)

1.4 (0.8, 3.0)

1.1 (0.1, 2.2)

MDA5 (+) vs. ARS (+), P < 0.05

IFI27

2.5 (0.6, 45.6)

0.6 (0.2, 25.5)

0.5 (0.3, 5.5)

IFN activation

10 (40%)

3 (16%)

3 (27%)

SDF-1α, pg/ml

392.4 (303.5, 551.9)

398.2 (331.0, 543.5)

496.8 (457.5, 551.2)

IP-10, pg/ml

15.9 (7.7, 25.4)

19.7 (11.1, 44.9)

16.9 (10.0, 44.4)

IL-7, pg/ml

0.6 (0.4, 1.0)

1.2 (0.7, 1.5)

0.6 (0.5, 1.5)

Eotaxin, pg/ml

16.9 (11.2, 27.0)

20.6 (8.1, 28.6)

17.6 (10.8, 27.8)

IL-17 A, pg/ml

1.1 (1.1, 1.1)

1.1 (1.1, 3.6)

1.1 (1.1, 2.3)

IL-1RA, pg/ml

42.4 (28.9, 192.8)

85.2 (12.9, 339.3)

41.8 (20.9, 50.9)

RANTES, pg/ml

20.3 (13.1, 41.5)

22.7 (17.0, 35.5)

29.2 (14.3, 43.0)

TNF-α, pg/ml

1.8 (1.8, 1.8)

1.8 (1.8, 1.8)

1.8 (1.8, 1.8)

MIP-1β, pg/ml

47.5 (32.0, 65.7)

49.0 (18.3, 79.9)

46.7 (35.5, 60.0)

MCP-1, pg/ml

16.5 (5.1, 75.7)

19.5 (8.7, 67.4)

20.8 (14.4, 41.7)

GRO-α, pg/ml

0.7 (0.7, 0.7)

0.7 (0.7, 0.7)

0.7 (0.7, 0.7)

IL-1α, pg/ml

0.3 (0.3, 0.3)

0.3 (0.3, 0.3)

0.3 (0.3, 0.6)

IL-18, pg/ml

5.6 (5.6, 27.0)

12.7 (5.6, 20.2)

5.6 (5.6, 10.0)

IL-21, pg/ml

4.8 (4.8, 4.8)

4.8 (4.8, 4.8)

4.8 (4.8, 4.8)

IL-22, pg/ml

6.8 (6.8, 6.8)

6.8 (6.8, 6.8)

6.8 (6.8, 6.8)