Fig. 3

Main findings. This figure illustrates the main findings of this study. Patients with a phenotype of persistently high serum interferon-α levels had a higher degree of cognitive dysfunction. Both patients with a phenotype of moderate-high SLEDAI-2 K and high interferon-α had a higher degree of structural MRI changes. Neuronal damage assessed by plasma neurofilament light levels was more prominent during visits with higher SLE disease activity