Table 4 Associations between MRI abnormalities and lupus phenotypes
MRI volumes [mm3/mm3] | High versus low IFN-α phenotype | Moderate-high versus low SLEDAI-2 K phenotype | ||
|---|---|---|---|---|
Estimated coefficient (95% CI) | P-value | Estimated coefficient (95% CI) | P-value | |
White matter lesion volume | -0.026 (-0.36–0.31) | 0.88 | 0.38 (0.089–0.66) | 0.011 |
Volume of all CSF spaces | 3.5*10− 5 (-3.5*10− 5– 1.1*10− 4) | 0.32 | 2.8*10− 5 (-3.7*10− 5– 9.3*10− 5) | 0.40 |
Total cortex volume | -0.0060 (-0.013–0.0013) | 0.10 | -0.0037 (-0.010–0.0029) | 0.26 |
Total white matter volume | -0.0040 (-0.010–0.0021) | 0.19 | 6.1*10− 4 (-0.0049–0.0061) | 0.83 |
Corpus callosum volume | -1.4*10− 4 (-3.1*10− 4– 4.0*10− 5) | 0.13 | -1.1*10− 4 (-2.7*10− 4– 4.0*10− 5) | 0.14 |
Total grey matter volume | -0.010 (-0.019– -6.5*10− 4) | 0.036 | -0.0088 (-0.017– -3.8*10− 4) | 0.041 |
Caudate nucleus volume | -3.3*10− 4 (-6.5*10− 4– -2.0*10− 5) | 0.038 | -1.8*10− 4 (-4.6*10− 4– 1.0*10− 4) | 0.20 |
Pallidus volume | -5.1*10− 5 (-1.8*10− 4– 7.6*10− 5) | 0.42 | -6.6 *10− 5 (-1.9*10− 4– 5. *10− 5) | 0.29 |
Putamen volume | -2.8*10− 4 (-6.3*10− 4 − 6.8*10− 5) | 0.11 | -2.0*10− 4 (-5.3*10− 4– 1.3*10− 4) | 0.22 |
Hippocampus volume | -1.3*10− 4 (-3.6*10− 4– 1.0*10− 4) | 0.27 | -8.7*10− 5 (-3.0*10− 4– 1.3*10− 4) | 0.42 |
Amygdala volume | -8.8 *10− 5 (-2.2*10− 4– 4.7*10− 5) | 0.20 | -3.8*10− 6 (-1.3*10− 4– 1.2*10− 4) | 0.95 |
Accumbens volume | -4.3*10− 5 (-1.2*10− 4 − 2.8*10− 5) | 0.23 | -2.0*10− 5 (-8.5 *10− 5– 4.5 *10− 5) | 0.54 |
Thalamus volume | -5.1*10− 4 (-9.4*10− 4– -7.4 *10− 5) | 0.023 | -5.3*10− 4 (-9.0*10− 4– -1.6*10− 4) | 0.005 |