Table 5 Associations between IFN-α lupus phenotypes and cognitive dysfunction
Cognitive dysfunction in specific domain: | Degree | IFN-α lupus phenotype | ||||
|---|---|---|---|---|---|---|
High | Low | P-value* | Odds ratio (95% CI) | P-value** | ||
Any domain | Moderate to severe | 70% | 39% | 0.026 | 3.5 (1.1–11.1) | 0.030 |
Mild to severe | 91% | 49% | 0.00087 | 11.0 (2.2–54.9) | 0.004 | |
At least two domains | Moderate to severe | 39% | 24% | 0.23 | 2.0 (0.61–6.3) | 0.26 |
Mild to severe | 65% | 36% | 0.034 | 3.1 (0.99–9.5) | 0.053 | |
Neurocognitive Index | Moderate to severe | 5% | 6% | 1.0 | ||
Mild to severe | 9% | 6% | 1.0 | |||
Composite Memory | Moderate to severe | 22% | 6% | 0.11 | ||
Mild to severe | 30% | 15% | 0.17 | |||
Complex Attention | Moderate to severe | 14% | 9% | 0.68 | ||
Mild to severe | 14% | 13% | 1.0 | |||
Cognitive Flexibility | Moderate to severe | 9% | 9% | 1.0 | ||
Mild to severe | 17% | 13% | 0.71 | |||
Psychomotor Speed | Moderate to severe | 4% | 3% | 1.0 | ||
Mild to severe | 17% | 6% | 0.22 | |||
Reaction Time | Moderate to severe | 22% | 18% | 0.74 | ||
Mild to severe | 39% | 18% | 0.13 | |||
Visual Memory | Moderate to severe | 22% | 6% | 0.11 | ||
Mild to severe | 30% | 9% | 0.073 | 4.2 (0.95–18.7) | 0.058 | |
Processing Speed | Moderate to severe | 9% | 3% | 0.62 | ||
Mild to severe | 26% | 6% | 0.035 | 7.9 (1.2–51) | 0.029 | |
Executive Function | Moderate to severe | 9% | 9% | 1.0 | ||
Mild to severe | 13% | 19% | 0.72 | |||
Simple Attention | Moderate to severe | 13% | 19% | 1.0 | ||
Mild to severe | 13% | 19% | 1.0 | |||
Motor Speed | Moderate to severe | 0% | 13% | 0.52 | ||
Mild to severe | 22% | 13% | 0.60 | |||
Verbal Memory | Moderate to severe | 17% | 6% | 0.22 | ||
Mild to severe | 26% | 15% | 0.31 | |||