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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway

Fig. 3

Tofacitinib dampens IL-21-induced B cell responses in a 6-day HD-PBMC culture. (A) Representative histograms (left) showing the effect of tofacitinib (Tofa) or control on the percentage of proliferating B cells, as measured by CFSE staining, under IL-21 or anti-CD40 stimulation. Gates were set using unstimulated cells as control. Quantification (right) of the percentage of proliferated B cells. (B) Representative dot plots (left) showing the gating of CD27+CD38+ plasmablasts within CD19+CD20+ B cells. Quantification (right) of the plasmablast proportions. (C) Concentration of IgG, IgM and IgA in culture supernatants from IL-21 (top) or anti-CD40 (bottom)-stimulated cells. Graphs show the mean, SD and individual values (*p < 0.05, n = 6 HD)

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Arthritis Research & Therapy

ISSN: 1478-6362

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