Table 1 Details of 15 ferroptosis related genes in rat IVD obtained from NCBI

Mtch1

Mitochondrial carrier 1

Chromosome 20, NC_086038.1 (7391558..7415291)

Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic process

Kdm5c

Lysine demethylase 5 C

Chromosome X, NC_086039.1 (24821568..24866423)

Predicted to enable histone H3-methyl-lysine- 4 demethylase activity and zinc ion binding activity

Phkg2

Phosphorylase kinase catalytic subunit gamma 2

Chromosome 1, NC_086019.1 (191614738..191627615)

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta

Nr1 d1

Nuclear receptor subfamily 1, group D, member 1

Chromosome 10, NC_086028.1 (84224599..84231812)

The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins

Tf

Transferrin

Chromosome 8, NC_086026.1 (112668667..112695376)

Enables ferric iron binding activity

Tsc1

TSC complex subunit 1

Chromosome 3, NC_086021.1 (32367434..32416565)

Enables GTPase activating protein binding activity and protein N-terminus binding activity

Epas1

Endothelial PAS domain protein 1

Chromosome 6, NC_086024.1 (13543252..13626147)

Enables DNA-binding transcription factor activity and cobalt ion binding activity

Ndrg1

N-myc downstream regulated 1

Chromosome 7, NC_086025.1 (100573526..100614902)

Predicted to enable cadherin binding activity; small GTPase binding activity; and tubulin binding activity

Nr1 d2

Nuclear receptor subfamily 1, group D, member 2

Chromosome 15, NC_086033.1 (9955034..9981329)

The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism

Atf3

Activating transcription factor 3

Chromosome 13, NC_086031.1 (105274103..105331653)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity

Gsk3b

Glycogen synthase kinase 3 beta

Chromosome 11, NC_086029.1 (76004502..76154665)

Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity

Scp2 d1

SCP2 sterol-binding domain containing 1

Chromosome 3, NC_086021.1 (152655282..152656032)

Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity

Timm9

Translocase of inner mitochondrial membrane 9

Chromosome 6, NC_086024.1 (95346065..95358895)

Predicted to enable chaperone binding activity; membrane insertase activity; and protein homodimerization activity

Kdm5a

Lysine demethylase 5 A

Chromosome 4, NC_086022.1 (155238124..155316121)

Predicted to enable several functions, including DNA binding activity; histone H3-tri/di/monomethyl-lysine- 4 demethylase activity; and zinc ion binding activity

Lpin1

Lipin 1

Chromosome 6, NC_086024.1 (45039110..45145845)

Predicted to enable several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity