Fig. 4

Persistence of the global spike protein-specific T-cell response over time. CD4⁺ and CD8 + T-cell global activation parameters were analyzed in blood samples from patients with RA treated with RTX (RA RTX +, n = 51). Samples were segregated according to the time between their last SARS-CoV- 2 boost (last vaccine or infection) and blood collection, with 3-month time intervals considered for each group. Green triangles refer to vaccinated patients who had no history of COVID- 19. Red triangles refer to vaccinated patients who had a history of COVID- 19. The orange line corresponds to the positivity threshold determined by ROC analysis