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Table 4 Correlations between static and dynamic indicators with disease duration, treatment, laboratory indicators, and neuropsychological assessments

From: Regional brain function study in patients with primary Sjögren’s syndrome

Indices

Brain region

MMSE

SAS

SDS

NCT-A

DST

IgG

IgA

IgM

C3

C4

SSB

SSA

Disease duration

Treatment

r/ P

r/ P

r/ P

r/ P

r/P

r/P

r/P

r/P

r/P

r/P

r/P

r/P

r/P

r/P

sfALFF

SMA_R

-0.019/0.890

-0.087/0.577

0.209/0.178

-0.187/0.188

0.058/0.697

0.200/0.113

0.122/0.339

0.074/0.561

-0.050/0.697

-0.164/0.195

0.236/0.060

0.047/0.714

0.008/0.950

0.054/0.671

sReHo

Frontal_Med_Orb_L

0.062/0.655

-0.163/0.297

-0.113/0.471

-0.125/0.380

0.085/0.571

0.071/0.576

0.064/0.614

0.084/0.510

-0.134/0.289

-0.148/0.243

-0.112/0.378

0.033/0.794

-0.066/0.605

0.036/0.778

Caudate_L

0.132/0.340

0.295/0.055

-0.037/0.815

-0.147/0.304

-0.082/0.584

-0.001/0.995

-0.012/0.924

0.134/0.292

-0.191/0.131

-0.060/0.638

0.115/0.365

0.102/0.420

-0.015/0.909

0.029/0.820

Precuneus_R

-0.032/0.821

-0.133/0.395

-0.223/0.150

-0.389/0.005*

0.266/0.071

0.122/0.337

-0.111/0.381

0.112/0.377

-0.134/0.290

-0.252/0.045

0.096/0.449

0.171/0.178

-0.130/0.307

-0.036/0.777

dfALFF

SMA_L

-0.109/0.434

-0.037/0.816

0.080/0.608

-0.096/0.501

0.168/0.253

0.187/0.139

0.131/0.301

0.137/0.279

-0.090/0.481

-0.128/0.312

0.286/0.022

0.062/0.625

-0.049/0.700

-0.081/0.527

dReHo

Frontal_Sup_R

-0.140/0.314

0.109/0.488

0.120/0.443

0.257/0.068

-0.390/0.007*

-0.218/0.083

0.001/0.994

0.058/0.651

0.125/0.325

0.231/0.067

-0.108/0.394

-0.224/0.075

0.040/0.752

-0.004/0.976

  1. Note: MMSE, Mini-Mental State Examination; SAS, Self-Rating Anxiety Scale; SDS, Self-rating Depression Scale; NCT-A, Number Connection Test-Type A; DST, Digit Symbol Test; sfALFF, static fractional amplitude of low-frequency fluctuation; sReHo, static regional homogeneity; dfALFF, dynamic fractional amplitude of low-frequency fluctuation; dReHo, dynamic regional homogeneity; SMA_R, right supplementary motor area; Frontal_Med_Orb_L, left orbital middle frontal gyrus; CAU_L, left caudate nucleus; PCUN_R, right precuneus lobe; SMA_L, left supplementary motor area; Frontal_Sup_R, right dorsolateral superior frontal gyrus; * indicates a significant level of P < 0.008