Table 2 Patient characteristics after IPTW
2 mg morning (n = 50) | 2 mg evening (n = 51) | P value | SMD | 4 mg morning (n = 52) | 4 mgevening (n = 53) | P value | SMD | |
|---|---|---|---|---|---|---|---|---|
Age, years | 67.4 ± 19.3 | 67.6 ± 15.2 | 0.73 | 0.01 | 59.1 ± 21.7 | 56.5 ± 31.2 | 0.62 | 0.09 |
Sex (male, female) | (3, 47) | (5, 47) | 0.49 | 0.06 | (11, 41) | (12, 41) | 0.85 | 0.04 |
Body mass index, kg/m2 | 23.2 ± 5.9 | 22.9 ± 3.8 | 0.81 | 0.06 | 22.6 ± 5.6 | 22.5 ± 6.6 | 0.95 | 0.01 |
Disease duration, years | 6.8 ± 10.7 | 6.3 ± 8.3 | 0.77 | 0.06 | 9.3 ± 10.6 | 9.4 ± 12.9 | 0.95 | 0.01 |
eGFR (ml/min) | 57.6 ± 24.7 | 62.8 ± 17.9 | 0.23 | 0.24 | 71.9 ± 25.5 | 69.9 ± 14.5 | 0.63 | 0.09 |
Positive for RF - no (%) | 45 (91.2) | 45 (88.2) | 0.62 | 0.1 | 45 (86.7) | 45 (83.4) | 0.63 | 0.09 |
Positive for ACPA - no (%) | 42 (84.4) | 45 (87.7) | 0.63 | 0.03 | 44 (84.8) | 46 (85.3) | 0.94 | 0.01 |
MTX use at baseline - no (%) | 32 (64.0) | 28 (54.4) | 0.27 | 0.19 | 38 (74.4) | 39 (73.4) | 0.91 | 0.02 |
MTX dose, mg/week | 4.9 ± 6.0 | 4.7 ± 6.6 | 0.86 | 0.03 | 5.2 ± 5.0 | 6.2 ± 6.2 | 0.36 | 0.18 |
GC use at baseline - no (%) | 25 (49.7) | 19(37.8) | 0.23 | 0.24 | 26 (50.2) | 24 (44.8) | 0.59 | 0.1 |
Prednisolone dose, mg/day | 1.6 ± 2.8 | 2.0 ± 4.2 | 0.59 | 0.1 | 2.0 ± 3.3 | 2.2 ± 3.0 | 0.75 | 0.06 |
Previous bDMARDs - no (%) (0/1/≧2) | 32/13/5 (64.0/26.6/9.4) | 32/15/4 (62.6/28.9/8.5) | 0.96 | 0.03 | 19/20/13 (36.5/38.5/25) | 21/22/10 (39.6/41.5/18.9) | 0.71 | 0.06 |
66-Swollen joint count | 4.6 ± 3.2 | 4.7 ± 3.2 | 0.96 | 0.02 | 4.6 ± 4.8 | 5.0 ± 4.7 | 0.64 | 0.07 |
68-Tender joint count | 3.7 ± 3.8 | 3.5 ± 3.6 | 0.82 | 0.05 | 3.9 ± 5.2 | 4.2 ± 5.6 | 0.81 | 0.03 |
PtGA, VAS, mm | 55.3 ± 36.0 | 55.5 ± 34.4 | 0.85 | 0.01 | 56.9 ± 36.3 | 55.3 ± 38 | 0.82 | 0.04 |
Patient pain, VAS, mm | 50.0 ± 36.5 | 52.4 ± 36.6 | 0.60 | 0.06 | 55.8 ± 42.7 | 57.6 ± 38 | 0.82 | 0.04 |
PGA VAS, mm | 49.8 ± 23.8 | 43.2 ± 23.6 | 0.16 | 0.28 | 38.5 ± 26 | 40.3 ± 20.4 | 0.69 | 0.07 |
HAQ-DI | 0.81 ± 0.87 | 0.78 ± 0.92 | 0.96 | 0.03 | 0.98 ± 1.1 | 0.92 ± 1.2 | 0.78 | 0.05 |
CRP, mg/l | 16.8 ± 26.6 | 20.1 ± 33.5 | 0.56 | 0.1 | 9.4 ± 1.1 | 12.7 ± 3.8 | 0.54 | 0.09 |
ESR, mm/h | 46.5 ± 43.7 | 54.3 ± 50.0 | 0.32 | 0.16 | 27.6 ± 31.8 | 24.5 ± 32.4 | 0.62 | 0.09 |
DAS28-CRP | 3.99 ± 1.37 | 3.86 ± 1.50 | 0.68 | 0.09 | 3.84 ± 1.24 | 3.76 ± 1.31 | 0.71 | 0.07 |
DAS28-ESR | 4.77 ± 1.38 | 4.69 ± 1.51 | 0.87 | 0.06 | 4.25 ± 1.22 | 4.15 ± 1.73 | 0.74 | 0.06 |
CDAI | 18.8 ± 8.8 | 18.0 ± 9.3 | 0.71 | 0.08 | 18.1 ± 12.6 | 18.8 ± 11.3 | 0.77 | 0.06 |
SDAI | 20.4 ± 10.7 | 20.0 ± 11.8 | 0.89 | 0.03 | 19.0 ± 12.8 | 20.1 ± 13.1 | 0.69 | 0.08 |