Table 2 Top 25 differentially expressed genesets in ACPA + RA vs. HCs

H_HALLMARK_E2F_TARGETS

190

Up

< 0.0001

< 0.0001

H_HALLMARK_G2M_CHECKPOINT

194

Up

< 0.0001

< 0.0001

C2_REACTOME_DNA_STRAND_ELONGATION

30

Up

< 0.0001

< 0.0001

C2_REACTOME_G2_M_CHECKPOINTS

41

Up

< 0.0001

0.0001

C2_REACTOME_G1_S_SPECIFIC_TRANSCRIPTION

16

Up

< 0.0001

0.0001

C2_REACTOME_DNA_REPLICATION

177

Up

< 0.0001

0.0001

C2_REACTOME_G1_S_TRANSITION

103

Up

< 0.0001

0.0003

C2_REACTOME_UNWINDING_OF_DNA

11

Up

< 0.0001

0.0003

C2_REACTOME_MITOTIC_G1_G1_S_PHASES

127

Up

< 0.0001

0.0003

C2_REACTOME_SYNTHESIS_OF_DNA

87

Up

< 0.0001

0.0003

C2_REACTOME_S_PHASE

103

Up

< 0.0001

0.0003

C2_REACTOME_MITOTIC_M_M_G1_PHASES

158

Up

< 0.0001

0.0004

C2_KEGG_DNA_REPLICATION

36

Up

< 0.0001

0.0005

H_HALLMARK_MYC_TARGETS_V1

194

Up

< 0.0001

0.0005

C2_REACTOME_ASPARAGINE_N_LINKED_

GLYCOSYLATION

75

Up

< 0.0001

0.0006

C2_REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_

REPLICATION_ STRESS

35

Up

< 0.0001

0.0006

H_HALLMARK_MTORC1_SIGNALING

190

Up

< 0.0001

0.0006

C2_REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION

32

Up

< 0.0001

0.0009

C2_KEGG_N_GLYCAN_BIOSYNTHESIS

43

Up

< 0.0001

0.0009

C2_REACTOME_CELL_CYCLE_CHECKPOINTS

107

Up

< 0.0001

0.0009

C2_REACTOME_CELL_CYCLE_MITOTIC

294

Up

< 0.0001

0.0011

C2_REACTOME_M_G1_TRANSITION

76

Up

< 0.0001

0.0011

C2_REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX

29

Up

< 0.0001

0.0027

C2_REACTOME_CELL_CYCLE

373

Up

< 0.0001

0.0028

C2_REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_

DNA_POL_IN_TC_NER

14

Up

< 0.0001

0.0034