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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients

Fig. 1

RRA analysis of the key genes and functional pathways from SLE monocytes, and verified the transcriptional signature gene set of SLE monocytes. (a) Identification of key differentially expressed genes through RRA analysis. (b) STRING network analysis illustrating the protein-protein interaction (PPI) network among these differentially expressed genes. (c) The network regulatory relationship diagram showed significantly enriched TFs and their regulatory targets. Red represents TFs and brown represents regulatory genes. (d) GSEA analysis based on the differentially expressed gene list from the RRA analysis. (e) GESA enrichment map of key signaling pathways. (f) GSEA analysis indicates a significant enrichment of the SLE monocyte transcriptional signature gene set in SLE patients. (g) The GSVA enrichment scores of the SLE monocyte transcriptional signature gene set compared with the control. (h) ROC analysis reveals that the GSVA enrichment scores of the SLE monocyte transcriptional signature gene set

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Arthritis Research & Therapy

ISSN: 1478-6362

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