Fig. 3

Differential expression analysis of transcriptomes of monocyte subsets in SLE patients and healthy controls. (a) Heatmap showing the expression of selected key ISGs in mononuclear phagocyte subsets of SLE patients and healthy controls. (b) Dot plot comparing the expression of selected key ISGs in mononuclear phagocyte subsets of SLE patients and healthy controls. (c) Feature plot comparing the expression of IFI6 and IRF7 in mononuclear phagocytes of SLE patients and healthy controls. (d) GSEA analysis showing the significantly upregulated signaling pathways in CD14Mono8 cells of SLE patients. (e) GSEA analysis showing the significantly upregulated signaling pathways in pDC of SLE patients