Table 1 Baseline demographics and patient characteristics stratified by inflammatory arthritis diagnosis

N (%)

132,672

106,098 (80.0)

21,871 (16.5)

6,643 (5.0)

Age, mean (SD)

60.36 (14.04)

61.77 (13.64)

56.26 (13.66)

49.36 (14.58)

Age groups, n (%)

 < 50

28,541 (21.5)

19,205 (18.1)

6,696 (30.6)

3,370 (50.7)

 50 to < 70

67,295 (50.7)

54,155 (51.0)

11,447 (52.3)

2,680 (40.3)

 ≥ 70

36,836 (27.8)

32,738 (30.9)

3,728 (17.0)

593 (8.9)

Gender, n (%)

 Male

37,217 (28.1)

25,048 (23.6)

9,316 (42.6)

3,534 (53.2)

 Female

95,455 (71.9)

81,050 (76.4)

12,555 (57.4)

3,109 (46.8)

Race, n (%)

 White

92,848 (70.0)

72,611 (68.4)

16,806 (76.8)

4,844 (72.9)

 Asian

3,709 (2.8)

2,873 (2.7)

622 (2.8)

259 (3.9)

 Black

14,363 (10.8)

12,724 (12.0)

1,282 (5.9)

491 (7.4)

 Hispanic

15,109 (11.4)

12,597 (11.9)

2,073 (9.5)

679 (10.2)

 Missing

6,643 (5.0)

5,293 (5.0)

1,088 (5.0)

370 (5.6)

Geographic region, n (%)

 Northeast

14,554 (11.0)

11,425 (10.8)

2,711 (12.4)

626 (9.4)

 South

64,744 (48.8)

52,301 (49.3)

10,429 (47.7)

3,203 (48.2)

 Midwest

31,935 (24.1)

25,299 (23.8)

5,470 (25.0)

1,496 (22.5)

 West

21,355 (16.1)

17,007 (16.0)

3,250 (14.9)

1,311 (19.7)

 Missing/unknown/Puerto Rico

84 (0.1)

66 (0.1)

11 (0.1)

7 (0.1)

Inflammatory arthritis diagnosis, n (%)

 RA

106,098 (80.0)

106,098 (100.0)

987 (4.5)

736 (11.1)

 PsA

21,871 (16.5)

987 (0.9)

21,871 (100.0)

278 (4.2)

 axSpA

6,643 (5.0)

736 (0.7)

278 (1.3)

6,643 (100.0)

Comorbidities, n (%)

 Alcohol use

3,498 (2.6)

2,642 (2.5)

702 (3.2)

198 (3.0)

 Asthma

24,762 (18.7)

20,305 (19.1)

3,731 (17.1)

1,094 (16.5)

 Arrhythmias

9,004 (6.8)

7,677 (7.2)

1,126 (5.1)

297 (4.5)

 Chronic kidney disease

15,770 (11.9)

13,481 (12.7)

1,985 (9.1)

461 (6.9)

 Chronic liver disease

20,755 (15.6)

16,329 (15.4)

3,796 (17.4)

997 (15.0)

 Chronic obstructive pulmonary disease

30,105 (22.7)

25,484 (24.0)

3,990 (18.2)

994 (15.0)

 Congestive heart failure

10,915 (8.2)

9,506 (9.0)

1,229 (5.6)

282 (4.2)

 Depression

36,104 (27.2)

28,906 (27.2)

6,007 (27.5)

1,763 (26.5)

 Diabetes

35,648 (26.9)

29,100 (27.4)

5,869 (26.8)

1,162 (17.5)

 Drug abuse

7,768 (5.9)

6,260 (5.9)

1,242 (5.7)

402 (6.1)

 Dyslipidemia

79,252 (59.7)

64,728 (61.0)

12,629 (57.7)

2,962 (44.6)

 Herpes simplex virus

4,322 (3.3)

3,468 (3.3)

713 (3.3)

219 (3.3)

 Herpes zoster (plus antivirals)

5,396 (4.1)

4,588 (4.3)

669 (3.1)

197 (3.0)

 Hypertension

84,241 (63.5)

69,207 (65.2)

12,994 (59.4)

3,147 (47.4)

 Ischemic heart disease

26,531 (20.0)

22,316 (21.0)

3,698 (16.9)

845 (12.7)

 Family history of ischemic heart disease

10,941 (8.2)

8,772 (8.3)

1,808 (8.3)

516 (7.8)

 Myocardial infarction

2,140 (1.6)

1,826 (1.7)

266 (1.2)

77 (1.2)

 Stroke

1,878 (1.4)

1,643 (1.5)

201 (0.9)

51 (0.8)

 MACE

4,149 (3.1)

3,574 (3.4)

494 (2.3)

131 (2.0)

 VTE

1,616 (1.2)

1,402 (1.3)

163 (0.7)

66 (1.0)

 Obesity

49,469 (37.3)

38,986 (36.7)

9,114 (41.7)

2,181 (32.8)

 Peripheral vascular disease

21,641 (16.3)

18,679 (17.6)

2,631 (12.0)

547 (8.2)

 Smoking (ever)

41,325 (31.1)

33,923 (32.0)

6,269 (28.7)

1,678 (25.3)

 Current smoking (past year)

6,930 (5.2)

5,747 (5.4)

1,008 (4.6)

287 (4.3)

Medications, n (%)

 Opioid use

78,933 (59.5)

63,549 (59.9)

12,675 (58.0)

3,956 (59.6)

 Zostavax vaccination

6,124 (4.6)

5,311 (5.0)

729 (3.3)

140 (2.1)

 Shingrix vaccination

8,518 (6.4)

6,911 (6.5)

1,367 (6.3)

356 (5.4)

Healthcare utilization

 ER visit (past year), n (%)

33,327 (25.1)

27,729 (26.1)

4,652 (21.3)

1,410 (21.2)

 ER visit (ever), n (%)

59,276 (44.7)

48,727 (45.9)

8,715 (39.8)

2,648 (39.9)

 Outpatient rheumatologist visit (past year), n (SD)

2.87 (2.09)

2.91 (2.13)

2.71 (1.93)

2.68 (2.06)

 Outpatient rheumatologist visit (ever), n (SD)

7.72 (10.58)

7.96 (10.86)

6.80 (9.43)

6.67 (9.41)

 Outpatient visit (past year), n (SD)

10.97 (7.78)

11.12 (7.80)

10.48 (7.60)

10.21 (7.83)

 Outpatient visit (ever), n (SD)

38.27 (43.90)

38.99 (44.84)

35.76 (39.84)

34.80 (40.21)