Fig. 2
From: Atf3 + senescent chondrocytes mediate meniscus degeneration in aging
Single-cell transcriptomic profiling of meniscal cells in young and aged rats. (A) Workflow of single-cell RNA sequencing (scRNA-seq) applied to meniscal tissue. (B) UMAP visualization showing 11 cell clusters identified in young (YM) and aged (AM) meniscal samples. (C) Sample origin mapping reveals minimal batch effects across YM and AM groups. (D) Violin plots of canonical marker genes indicating chondrocytes. (E, F) Gene Ontology (GO) enrichment analysis for differentially expressed genes between YM and AM. (E) GO terms enriched in genes upregulated in AM. (F) GO terms enriched in genes downregulated in AM. X-axis: Rich factor; Y-axis:–log10(p-value)