Table 2 Incidence of development of RA, OA, and OA with joint replacement after truncal or superselective vagotomy, with respect to matched general population comparison cohorts
From: Vagotomy and the incidence of rheumatoid arthritis and osteoarthritis: a Danish register-based study
Truncal Vagotomy Cohort (n = 2260) | General Population Comparison Cohort (n = 22610) | Superselective Vagotomy Cohort (n = 3810) | General Population Comparison Cohort (n = 38090) | |
|---|---|---|---|---|
Incident RA, n* (%) | 10 (0.7) | 70 (0.3) | 10 (0.3) | 80 (0.2) |
IR (95% CI) for RA | 10.2 (6.5–15.3) | 7.2 (6.1–8.4) | 12.1 (8.8–16.1) | 8.9 (8.0–9.9) |
Crude HR (95% CI) for RA | 2.49 (1.40–4.43) | 1.0 | 1.05 (0.51–2.16) | 1.0 |
Adjusted HR (95% CI)** for RA | 2.62 (1.47–4.67) | 1.0 | 1.05 (0.51–2.17) | 1.0 |
Incident OA, n* (%) | 30 (1.3) | 350 (1.5) | 30 (0.8) | 340 (0.9) |
IR (95% CI) for OA | 46.9 (38.4–56.7) | 70.2 (66.8–73.7) | 85.9 (76.8–95.7) | 87.1 (84.2–90.2) |
Crude HR (95% CI) for OA | 1.11 (0.77–1.59) | 1.0 | 0.98 (0.68–1.40) | 1.0 |
Adjusted HR (95% CI)** for OA | 1.26 (0.88–1.81) | 1.0 | 1.00 (0.69–1.44) | 1.0 |
Incident OA w/JR, n* (%) | 10 (0.4) | 160 (0.7) | 10 (0.3) | 120 (0.3) |
IR (95% CI) for OA w/JR | 25.7 (19.5–33.2) | 45.7 (42.9–48.6) | 50.4 (43.5–58.1) | 60.4 (57.9–62.9) |
Crude HR (95% CI) for OA w/JR | 0.61 (0.30–1.23) | 1.0 | 0.69 (0.34–1.40) | 1.0 |
Adjusted HR (95% CI)** for OA w/JR | 0.77 (0.38–1.57) | 1.0 | 0.71 (0.35–1.46) | 1.0 |