Volume 4 Supplement 1

22nd European Workshop for Rheumatology Research

Meeting abstracts

The organizer would like to thank the following companies who have generously supported the 22nd European Workshop for Rheumatology Research: Abbott/Knoll, MSD, Wyeth Ayerst, Amgen, Centocor, Novartis, Schering Plough, Aventis

22nd European Workshop for Rheumatology Research.

Leiden, The Netherlands28 February - 3 March 2002

Page 1 of 3

HIF-1 mediated upregulation of VEGF and VEGF-R in systemic sclerosis (SSc): Imbalance with angiostatic factors suggests VEGF as a novel option for the treatment of ischemia in patients with SSc

Authors: O Distler, A Scheid, A Del Rosso, J Rethage, M Neidhart, RE Gay, U Müller-Ladner, M Gassmann, M Matucci-Cerinic and S Gay

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):1

Content type: Meeting abstract Published on: 4 February 2002
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Osteoclasts are essential for TNF-mediated joint destruction

Authors: KR Redlich, S Hayer, R Ricci, JP David, M Tohidast-Akrad, J Zwerina, G Kollias, G Steiner, JS Smolen, E Wagner and G Schett

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):10

Content type: Meeting abstract Published on: 4 February 2002
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Non viral gene therapy in arthritis by in vivo intramuscular IL-10 DNA electrotransfer

Authors: CJ Jorgensen, F Apparailly, N Perez, V Millet, D Greuet, C Minot, O Danos and J Sany

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):100

Content type: Meeting abstract Published on: 4 February 2002
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Alefacept treatment in psoriatic arthritis: reduction of the synovial inflammatory infiltrate and improvement of clinical signs of arthritis

Authors: MC Kraan, HJ Dinant, AWR van Kuijk, AY Goedkoop, TJM Smeets, MA de Rie, BAC Dijkmans, AK Vaishnaw and PP Tak

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):101

Content type: Meeting abstract Published on: 4 February 2002
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Chemokine blockade in patients with rheumatoid arthritis: reduction of synovial inflammation

Authors: JJ Haringman, MC Kraan, TJM Smeets and PP Tak

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):102

Content type: Meeting abstract Published on: 4 February 2002
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High dose cyclophosphamide followed by autologous stem cell transplantation for the treatment of intractable rheumatoid arthritis (RA): a 2-year clinical and immunological follow-up

Authors: RJ Verburg, JK Sont, A Kruize, F van den Hoogen, FC Breedveld and JM van Laar

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):103

Content type: Meeting abstract Published on: 4 February 2002
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Mycophenolate mofetil prevents the development of a clinical relapse in SLE patients at risk: an open pilot study

Authors: M Bijl, G Horst, H Bootsma, PC Limburg and CGM Kallenberg

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):104

Content type: Meeting abstract Published on: 4 February 2002
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Reduction of cartilage destruction in a rapid progressive arthritis model in SCID mice

Authors: U Sack, A Hirth, B Funke, K Wiedeneyer, F Kahlenberg, U Anderegg, F Krahnert, J Lehmann and F Emmrich

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):105

Content type: Meeting abstract Published on: 4 February 2002
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Selective elimination of inflammatory macrophages by Fcγ-RI-directed immunotoxins: a novel concept in the treatment of rheumatoid arthritis

Authors: JAG van Roon, S Wijngaarden, AJ van Vuuren, JWJ Bijlsma, FPJG Lafeber, JGJ van de Winkel and T Thepen

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):106

Content type: Meeting abstract Published on: 4 February 2002
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Long term immune reconstitution after immunoablation and autologous CD34 cell therapy in autoimmune diseases

Authors: AT Thiel, A Thiel, T Alexander, O Rosen, E Gromnica-Ihle, GR Burmester, R Arnold, F Hiepe and A Radbruch

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):107

Content type: Meeting abstract Published on: 4 February 2002
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A new non-viral vector for gene-therapy in rheumatic diseases

Authors: MJBM Vervoordeldonk, J Adriaansen, S Vanderbyl, G de Jong and PP Tak

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):108

Content type: Meeting abstract Published on: 4 February 2002
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Effects of TIMP-1 and TIMP-3 gene transfer on invasiveness, proliferation and apoptosis of rheumatoid arthritis (RA) synovial fibroblasts (RA-SF)

Authors: T Pap, A Drynda, CA Seemayer, PHA Quax, JH Verheijen, S Drynda, TWJ Huizinga, BA Michel, RE Gay, S Gay and WH van der Laan

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):109

Content type: Meeting abstract Published on: 4 February 2002
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Interaction of intimal fibroblasts with intracavitary fibrin: a morphologic follow up in ovalbumin arthritis

Authors: O Sánchez-Pernaute, R Largo, I Díez-Ortego, MA Alvarez-Soria, E Calvo, M Lopez-Armada and G Herrero-Beaumont

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):11

Content type: Meeting abstract Published on: 4 February 2002
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Suppression of in vitro and in vivo parameters of inflammatory synovitis by simvastatin

Authors: JA Gracie, D McCarey, BP Leung, M Prach, A Crilly, SE Robertson, R Madhok, JD Young, FY Liew, N Sattar and IB McInnes

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):110

Content type: Meeting abstract Published on: 4 February 2002
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Electrotransfer of low doses of plasmid encoding interleukin-10 in gene therapy of collagen-induced arthritis

Authors: Mc Boissier

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):111

Content type: Meeting abstract Published on: 4 February 2002
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A simple system for rapid generation of recombinant adenoviruses by ligation

Authors: J Dudler, R Salvi, R Driscoll and AK So

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):112

Content type: Meeting abstract Published on: 4 February 2002
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Biopsy-verified response of severe lupus nephritis to rituximab (anti-CD20 monoclonal antibody) plus cyclophosphamide after biopsy-documented failure to respond to NIH-protocol cyclophosphamide

Authors: RF van Vollenhoven, I Gunnarsson, E Welin-Henriksson, S Jacobson and L Klareskog

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):113

Content type: Meeting abstract Published on: 4 February 2002
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Immunodiagnosis and therapeutic immunosuppression in rheumatoid arthritis with ior t1 (anti-CD6) monoclonal antibody

Authors: E Montero, G Reyes, M Guibert, O Torres, N Rodriguez, J Estrada, L Torres, R Perez, A Hernandez and A Lage

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):114

Content type: Meeting abstract Published on: 4 February 2002
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Vascular endothelial growth factor (VEGF) expression in muscle tissue and the effect of corticosteroid therapy in patients with poly- and dermatomyositis

Authors: IE Lundberg

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):12

Content type: Meeting abstract Published on: 4 February 2002
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Etiology of a spontaneous autoimmune joint disease in mice

Authors: J Sinkora

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):13

Content type: Meeting abstract Published on: 4 February 2002
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Investigation of serum cartilage oligomer protein (COMP) levels in rheumatoid arthritis (RA)

Authors: M Brozik, L Hodinka, E Palkonyai, I Sznts, M Seszták, Zs Schmidt, U Böhm and K Merétey

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):14

Content type: Meeting abstract Published on: 4 February 2002
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Increased FcγRII and III expression in synovium and on monocyte derived macrophages of RA-patients results in altered function after immune complex stimulation

Authors: AB Blom, PLEM van Lent, TRDJ Radstake, AEM Holthuysen, AW Slöetjes, RL Smeets, P Barrera, LAB Joosten and WB van den Berg

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):15

Content type: Meeting abstract Published on: 4 February 2002
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IL-18 expression in synovial biopsies of patients with active rheumatoid arthritis is associated with enhanced levels of both IL-1 and TNFα

Authors: LAB Joosten, P Barrera, E Lubberts, AB Blom, B Oppers-Walgreen, LAM van den Bersselaa and WB van den Berg

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):16

Content type: Meeting abstract Published on: 4 February 2002
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A gene in the telomeric HLA complex distinct from HLA-A is involved in predisposition to juvenile idiopathic arthritis (JIA)

Authors: A Smerdel, BA Lie, R Ploski, BPC Koeleman, E Thorsby, O Førre and DE Undlien

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):17

Content type: Meeting abstract Published on: 4 February 2002
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Differential gene expression of proliferating synovial fibroblasts in rheumatoid arthritis

Authors: KM Masuda, R Masuda, M Neidhart, BR Simmen, BA Michel, U Müller-Ladner, RE Gay and S Gay

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):18

Content type: Meeting abstract Published on: 4 February 2002
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An approach to the analysis of gene expression in chronically activated T Lymphocytes

Authors: AP Cope, JM Clark, M Panesar, P Vagenas, T Freeman and PA Lyons

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):19

Content type: Meeting abstract Published on: 4 February 2002
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Comparison of the features of arthroscopic synovial biopsies with biopsy samples obtained at surgery

Authors: TJM Smeets, MC Kraan, E Barge, MD Smith and PP Tak

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):2

Content type: Meeting abstract Published on: 4 February 2002
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Efficacy of retroviral gene transfer into synovial fibroblasts is reduced by co-transduction with adenoviral vectors

Authors: U Müller-Ladner, O Distler, S Gay, E Neumann, M Judex, J Grifka, CH Evans and PD Robbins

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):20

Content type: Meeting abstract Published on: 4 February 2002
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Family collections for the analysis of common autoimmune disease genes in systemic rheumatic and inflammatory diseases

Authors: I Melchers, U Buchegger-Podbielski, A Feldmeyer and P Lodemann

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):21

Content type: Meeting abstract Published on: 4 February 2002
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A polymorphism within the Transforming Growth Factor β1 gene is associated with ankylosing spondylitis (AS)

Authors: F McGarry, L Cousins, RD Sturrock and M Field

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):22

Content type: Meeting abstract Published on: 4 February 2002
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The association of HLA-DR/DQ coding and QBP promoter allelic polymorphism with antiphospholipid antibody response in SLE

Authors: D Logar, B Vidan-Jeras, A Ambrozic, V Dolzan, M Hojnik, B Bozic and B Rozman

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):23

Content type: Meeting abstract Published on: 4 February 2002
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Expression of PAD enzymes and occurrence of citrulline-containing proteins in human blood and synovial fluid cells

Authors: ER Vossenaar, WAM van Mansum, A van der Heijden, S Nijenhuis, MAM van Boekel and WJ van Venrooij

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):24

Content type: Meeting abstract Published on: 4 February 2002
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Two promoters for the CD5 gene: one operating in T cells and activated B cells and another restricted to resting B cells

Authors: Y Renaudineau, N Haget and P Youinou

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):25

Content type: Meeting abstract Published on: 4 February 2002
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Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at position 67 to 74 of the HLA-DRB1 molecule

Authors: N de Vries, H Tijssen, PLCM van Riel and LBA van de Putte

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):26

Content type: Meeting abstract Published on: 4 February 2002
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Genome-wide gene expression in experimental arthritis: defining new targets of chronic/destructive rheumatoid arthritis (RA)

Authors: N Takahashi, T Boenafaes, B Ostendorf, ASK de Hooge, E Lubberts, PLEM van Lent, P Rottiers, FAJ van de Loo, LAB Joosten, J Grooten and WB van den Berg

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):27

Content type: Meeting abstract Published on: 4 February 2002
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Discovery of distinctive gene expression profiles in human arthritides by cDNA micro-array analysis

Authors: TCTM van der Pouw Kraan, FA van Gaalen, P Kasperkovitz, N Verbeet, AA Alizadeh, M Fero, TWJ Huizinga, E Pieterman, FC Breedveld, LM Staudt, D Botstein, PO Brown and CL Verweij

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):28

Content type: Meeting abstract Published on: 4 February 2002
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TNF-α blockade in early rheumatoid significantly reduces serum VEGF and ultrasonographic measures of synovitis and joint vascularity by 18 weeks

Authors: PC Taylor, A Steuer, P Charles, J Gruber, D Cosgrove, C Blomley, C Wagner and RN Maini

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):29

Content type: Meeting abstract Published on: 4 February 2002
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Epstein-Barr virus load in rheumatoid arthritis patients and normal controls: accurate quantification using real time PCR

Authors: N Pieri-Balandraud, D Reviron, J Roudier and C Roudier

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):3

Content type: Meeting abstract Published on: 4 February 2002
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Expression of galectin-3 in rheumatoid arthritis synovium

Authors: M Neidhart, S Kuchen, C Seemayer, RE Gay, BA Michel and S Gay

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):30

Content type: Meeting abstract Published on: 4 February 2002
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Bacterial peptidoglycan stimulates integrin expression and MMP production of synovial fibroblasts

Authors: DK Kyburz, J Rethage, R Seibl, BA Michel, RE Gay, DA Carson and S Gay

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):31

Content type: Meeting abstract Published on: 4 February 2002
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Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. An investigation of lymphocyte migration to secondary lymphoid organs

Authors: MC Blades, A Manzo, F Ingegnoli, P Taylor, H Irjala, S Jalkanen, DO Haskard, M Perretti, GS Panayi and C Pitzalis

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):32

Content type: Meeting abstract Published on: 4 February 2002
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Identification of homing peptides specific for synovial microvascular endothelium using in vivo phage display selection

Authors: L Lee, C Buckley, MC Blades, G Panayi, AJT George and C Pitzalis

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):33

Content type: Meeting abstract Published on: 4 February 2002
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Inmunohistologic analysis of synovial tissue from early and late osteoarthritic patients. A potential role for COX-2 and NF-κB1 (p50) regulation in early disease

Authors: MJ Benito, O FitzGerald and B Bresnihan

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):34

Content type: Meeting abstract Published on: 4 February 2002
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Comparison of knee joints with small joints: implications for pathogenesis and evaluation of treatment in rheumatoid arthritis

Authors: MC Kraan, RJ Reece, TJM Smeets, DJ Veale, P Emery and PP Tak

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):35

Content type: Meeting abstract Published on: 4 February 2002
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Expression of the EGF-TM7 family members EMR-2 and CD97 in rheumatoid synovial tissue

Authors: EN Kop, J Hamann, GJ Teske, M Kwakkenbos, TJM Smeets, MC Kraan, PP Tak and RAW van Lier

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):36

Content type: Meeting abstract Published on: 4 February 2002
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IgG-mediated activation of leukocytes is independent of Fc-γ receptor polymorphism

Authors: HM Dijstelbloem, AA Rarok, MG Huitema, JGJ van de Winkel, PC Limburg and CGM Kallenberg

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):37

Content type: Meeting abstract Published on: 4 February 2002
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Overexpression of the autoantigen hnRNP-A2 (RA33), the tumour suppressor p53 and activated MAP-Kinase p38 in inflamed synovial tissue

Authors: S Hayer, M Tohidast-Akrad, G Schett, H El Gabalawy, J Smolen and G Steiner

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):38

Content type: Meeting abstract Published on: 4 February 2002
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HMGB1 is a potent proinflammatory mediator expressed abundantly in chronic synovitis

Authors: UG Andersson, H Erlandsson Harris, R Kokkola, E Sundberg, A-K Ulfgren and K Palmblad

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):39

Content type: Meeting abstract Published on: 4 February 2002
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Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium

Authors: A-K Ulfgren, A Anca Irinel Catrina, LG Lollo Gršndal, SL Staffan Lindblad and LK Lars Klareskog

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):4

Content type: Meeting abstract Published on: 4 February 2002
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Expression of protease-activated receptors in arthritic synovial tissues

Authors: AK So, V Chobas-Péclat, C Morard and N Busso

Citation: Arthritis Research & Therapy 2002 4(Suppl 1):40

Content type: Meeting abstract Published on: 4 February 2002
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22nd European Workshop for Rheumatology Research

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