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  1. Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, co...

    Authors: Molly Klimak, Amanda Cimino, Kristin L. Lenz, Luke E. Springer, Kelsey H. Collins, Natalia S. Harasymowicz, Nathan Xu, Christine T.N. Pham and Farshid Guilak
    Citation: Arthritis Research & Therapy 2024 26:190
    Content type: Research Published on:

  2. Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of ...

    Authors: Stephanie L. Smith, Lorna Paul, Martijn P. M. Steultjens and Rebecca L. Jones
    Citation: Arthritis Research & Therapy 2024 26:189
    Content type: Review Published on:

  3. Patients with rheumatoid arthritis (RA) commonly experience a high prevalence of multiple metabolic diseases (MD), leading to higher morbidity and premature mortality. Here, we aimed to investigate the pathoge...

    Authors: Xiaoting Zhu, Wubin Long, Jing Zhang, Congcong Jian, Jianghua Chen, Jiaxin Huang, Shilin Li, Jie Zhang, Liang Wang, Yan Chen, Jianhong Wu, Tingting Wang, Qinghua Zou, Jing Zhu and Fanxin Zeng
    Citation: Arthritis Research & Therapy 2024 26:188
    Content type: Research Published on:

  4. Patients with diffuse cutaneous systemic sclerosis (dcSSc) frequently show spontaneous improvement of skin fibrosis. Our aim was to examine whether an improvement in skin fibrosis predicts lower likelihood of...

    Authors: Anja Wyss, Suzana Jordan, Nicole Graf, Patricia E. Carreira, Jörg Distler, Marco Matucci Cerinic, Elise Siegert, Jörg Henes, Elisabetta Zanatta, Valeria Riccieri, Marie-Elise Truchetet, Fahrettin Oksel, Mengtao Li, Eugene J. Kucharz, Kilian Eyerich, Francesco Del Galdo…
    Citation: Arthritis Research & Therapy 2024 26:187
    Content type: Research Published on:

  5. Rheumatoid arthritis (RA) is a clinically heterogeneous and complex autoimmune disease, making the prediction of therapeutic responses a significant challenge. This study aims to assess the role of clinical an...

    Authors: Jian Bin Li, Peng Cheng Liu, Liming Chen and Rui Wu
    Citation: Arthritis Research & Therapy 2024 26:186
    Content type: Research Published on:

  7. Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-positvie DM) is a subtype of dermatomyositis with a poor prognosis, characterized by rapidly progressive intersti...

    Authors: Yuanyuan Niu, Suling Liu, Qian Qiu, Di Fu, Youjun Xiao, Liuqin Liang, Yang Cui, Shanhui Ye and Hanshi Xu
    Citation: Arthritis Research & Therapy 2024 26:184
    Content type: Research Published on:

  8. Neuropsychiatric systemic lupus erythematosus (NPSLE) often manifests as cognitive deterioration, with activated microglia and blood-brain barrier (BBB) disruption implicated in these neurological complication...

    Authors: Liping Tan, Yu Fan, Xinyi Xu, Tianshu Zhang, Xiangyu Cao, Chenghao Zhang, Jun Liang, Yayi Hou and Huan Dou
    Citation: Arthritis Research & Therapy 2024 26:183
    Content type: Research Published on:

  9. Autologous haematopoietic stem cell transplantation (AHSCT) is more effective than conventional immunosuppressive therapies (CIT) in improving the outcome of patients with rapidly progressive diffuse cutaneous...

    Authors: Nicoletta Del Papa, Silvia Cavalli, Andrea Rindone, Francesco Onida, Giorgia Saporiti, Antonina Minniti, Maria Rosa Pellico, Claudia Iannone, Giorgia Trignani, Nicoletta D’Angelo, Manuel Sette, Raffaella Greco, Claudio Vitali and Roberto Caporali
    Citation: Arthritis Research & Therapy 2024 26:182
    Content type: Research Published on:

  11. Low-dose IL-2 (Ld-IL2) has shown favorable therapeutic effects in systemic lupus erythematosus (SLE) therapy. However, previous clinical trials reported an SLE Responder Index-4 (SRI-4) response rate of 65.52%...

    Authors: Ruiling Feng, Xian Xiao, Bo Huang, Kai Zhang, Xia Zhang, Zhanguo Li, Yuan Jia and Jing He
    Citation: Arthritis Research & Therapy 2024 26:180
    Content type: Research Published on:

  12. Arthritis notably elevates mortality risk. It remains unclear whether the cardiovascular health (CVH) metrics improves the risk of all-cause mortality in patients with all types of arthritis.

    Authors: Yu Zhu, Yang-Zhen Wang, Yi-tian Chen, Jie Guo and Zhen-Zhong Wang
    Citation: Arthritis Research & Therapy 2024 26:179
    Content type: Research Published on:

  13. Activated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis (RA). Despite the use of disease-modifying drugs, only about 50% of RA patients reach r...

    Authors: Beatrice Bergström, Tilia Selldén, Miriam Bollmann, Mattias N. D. Svensson and Anna-Karin Hultgård Ekwall
    Citation: Arthritis Research & Therapy 2024 26:178
    Content type: Research Published on:

  14. Authors: Andreas Reich, Anja Weiß, Lisa Lindner, Xenofon Baraliakos, Denis Poddubnyy, Silke Zinke, Carsten Stille, Anja Strangfeld and Anne C. Regierer
    Citation: Arthritis Research & Therapy 2024 26:177
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:136

  15. Mechanobiological mechanisms of osteoarthritis (OA) are unclear. Our objectives were to explore: 1) changes in knee joint physiology using a large panel of synovial fluid biomarkers from before to one year aft...

    Authors: Jenna M. Schulz, Trevor B. Birmingham, Holly T. Philpott, C. Thomas Appleton, Hayden F. Atkinson, J. Robert Giffin and Frank Beier
    Citation: Arthritis Research & Therapy 2024 26:176
    Content type: Research Published on:

  16. Pain, the primary complaint in rheumatoid arthritis (RA), is multifaceted, and may be driven by inflammatory disease activity and central sensitisation. We aimed to ascertain what proportion of RA pain severit...

    Authors: Vasileios Georgopoulos, Stephanie Smith, Daniel F. McWilliams, Eamonn Ferguson, Richard Wakefield, Dorothy Platts, Susanne Ledbury, Deborah Wilson and David A. Walsh
    Citation: Arthritis Research & Therapy 2024 26:175
    Content type: Research Published on:

  17. Patients with radiographic axial spondyloarthritis (r-axSpA) are at increased risk of incident cardiovascular events. Tumor necrosis factor inhibitors (TNFi) have shown a protective effect against incident car...

    Authors: Oh Chan Kwon, Hye Sun Lee, So Young Jeon and Min-Chan Park
    Citation: Arthritis Research & Therapy 2024 26:174
    Content type: Research Published on:

  18. CXC chemokine CXCL12 is involved in the pathological development of rheumatoid arthritis (RA) through abnormal migration of peripheral immune cells in the joint. Although low dose methotrexate (MTX) is clinica...

    Authors: Lei Ding, Daniel H. Park, Bo Gao, Lingyuan Wu, Meizhang Li, Haitham Abedelhakim and Ming Zhang
    Citation: Arthritis Research & Therapy 2024 26:173
    Content type: Research Published on:

  19. to evaluate over a 48-month follow-up period the: 1) long-term effectiveness and safety; 2) drug retention rate (DRR); 3) impact of comorbidities and bDMARDs line on MDA and DAPSA remission/low disease activit...

    Authors: Roberta Ramonda, Mariagrazia Lorenzin, Maria Sole Chimenti, Fabiola Atzeni, Angelo Semeraro, Salvatore D’Angelo, Carlo Selmi, Augusta Ortolan, Antonio Marchesoni, Maria Manara, Michele Maria Luchetti Gentiloni, Leonardo Santo, Carlo Salvarani, Alberto Cauli, Maurizio Rossini, Giorgio Amato…
    Citation: Arthritis Research & Therapy 2024 26:172
    Content type: Research Published on:

  20. Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes (T2D), we evaluated the synovial tissue expression of IL-1 related genes in relationsh...

    Authors: Piero Ruscitti, Damiano Currado, Felice Rivellese, Marta Vomero, Luca Navarini, Paola Cipriani, Costantino Pitzalis and Roberto Giacomelli
    Citation: Arthritis Research & Therapy 2024 26:171
    Content type: Research Published on:

  21. Endothelial progenitor cells (EPCs) are essential for maintenance of vascular homeostasis and stability, key processes in the pathogenesis of systemic lupus erythematosus (SLE). However, the role and phenotypi...

    Authors: Carlos Rafael-Vidal, Sara Martínez-Ramos, Beatriz Malvar-Fernández, Irene Altabás-González, Coral Mouriño, Pablo Pazos-López, Arturo Fraga-Bau, José María Pego Reigosa and Samuel García
    Citation: Arthritis Research & Therapy 2024 26:170
    Content type: Research Published on:

  22. Little is known about the symptoms at the onset of Sjögren’s Disease (SjD) and it is unclear whether SjD starts with characteristic symptoms that could be differentiated from dryness of other origin (sicca syn...

    Authors: Angelika Lackner, Barbara Dreo, Josef Hermann, Sabine Zenz, Johannes Fessler, Jens Thiel and Martin Helmut Stradner
    Citation: Arthritis Research & Therapy 2024 26:169
    Content type: Research Published on:

  23. Untreated acute ankle sprains often result in chronic ankle instability (CAI) and can ultimately lead to the development of post-traumatic osteoarthritis (PTOA). At present, a typical animal model of ankle ins...

    Authors: Yan Du, Shuo Wang, Fanlei Yang, Hao Xu, Yu Cheng and Jia Yu
    Citation: Arthritis Research & Therapy 2024 26:168
    Content type: Research Published on:

  24. Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using di...

    Authors: Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear and Anne Crilly
    Citation: Arthritis Research & Therapy 2024 26:167
    Content type: Research Published on:

  25. This study investigated whether serum syndecan1 at diagnosis reflects activity at diagnosis and predicts poor outcomes during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated va...

    Authors: Taejun Yoon, Jang Woo Ha, Jung Yoon Pyo, Eunhee Ko, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee
    Citation: Arthritis Research & Therapy 2024 26:166
    Content type: Research Published on:

  26. The aims of this study were to suggest patient-adjusted optical spectral transmission (OST) cut-off values for the first time and to develop clinical models that predict the probability of an early rheumatoid ...

    Authors: Konstantinos Triantafyllias, Khalid K. Altamimi, Florian Schederecker and Andreas Schwarting
    Citation: Arthritis Research & Therapy 2024 26:165
    Content type: Research Published on:

  27. Systemic autoimmune rheumatic diseases (SARDs) related pulmonary disease is highly prevalent, with variable clinical presentation and behavior, and thus is associated with poor outcomes and negatively impacts ...

    Authors: Yukai Wang, Shaoqi Chen, Shaoyu Zheng, Zexuan Zhou, Weijin Zhang, Guangzhou Du, Angelina Mikish, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Luna Gargani, Marco Matucci-Cerinic and Daniel E Furst
    Citation: Arthritis Research & Therapy 2024 26:164
    Content type: Review Published on:

  28. To investigate the efficacy and safety of belimumab in the treatment of systemic lupus erythematosus (SLE) in a real-world setting and provide a valuable reference for clinical treatment.

    Authors: Zhaohui Su, Chunyi Zhang, Congcong Gao, Chaoying Li, Ruxv Li and Zhaohui Zheng
    Citation: Arthritis Research & Therapy 2024 26:163
    Content type: Research Published on:

  29. Chronic pain and inflammation are common features of rheumatic conditions such as Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (axSpA), often needing prolonged medication treatment for effective manag...

    Authors: Damiano Currado, Francesca Saracino, Piero Ruscitti, Annalisa Marino, Ilenia Pantano, Marta Vomero, Onorina Berardicurti, Viktoriya Pavlych, Claudio Di Vico, Francesco Caso, Luisa Costa, Marco Tasso, Federica Camarda, Francesca Misceo, Francesco De Vincenzo, Addolorata Corrado…
    Citation: Arthritis Research & Therapy 2024 26:162
    Content type: Research Published on:

  30. The current EULAR definition of difficult-to-treat rheumatoid arthritis (D2T-RA) identifies patients with active disease refractory to multiple treatments at a single time point, without considering the persis...

    Authors: Gilberto Cincinelli, Gabriella Maioli, Cristina Posio, Ennio Giulio Favalli, Francesca Ingegnoli and Roberto Caporali
    Citation: Arthritis Research & Therapy 2024 26:161
    Content type: Research Published on:

  31. The Manhattan Lupus Surveillance Program (MLSP), a population-based retrospective registry of patients with systemic lupus erythematosus (SLE), was used to investigate the prevalence of cardiovascular disease ...

    Authors: Daniel P. Joyce, Jeffrey S. Berger, Allison Guttmann, Ghadeer Hasan, Jill P. Buyon, H. Michael Belmont, Jane Salmon, Anca Askanase, Joan Bathon, Laura Geraldino-Pardilla, Yousaf Ali, Ellen M. Ginzler, Chaim Putterman, Caroline Gordon, Charles G. Helmick, Kamil E. Barbour…
    Citation: Arthritis Research & Therapy 2024 26:160
    Content type: Research Published on:

  32. Systemic lupus erythematosus (SLE) is the quintessential autoimmune disease, as it is characterized by hyperactivity of CD4+ T cells and subsequently drives lupus pathology. Follicular helper T (TFH) cells play a...

    Authors: Tipanan Khunsri, Pongsakorn Thawornpan, Pachara Tianpothong, Thanitta Suangtamai, Pintip Ngamjanyaporn, Chaniya Leepiyasakulchai, Kittikorn Wangriatisak, Prapaporn Pisitkun and Patchanee Chootong
    Citation: Arthritis Research & Therapy 2024 26:159
    Content type: Research Published on:

  33. Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies are one of the myositis-specific antibodies which is associated with immune-mediated necrotizing myopathy (IMNM). However, the relati...

    Authors: Hongxia Yang, Chao Sun, Lifang Ye, Yuetong Xu, Sang Lin, Qinglin Peng, Guochun Wang and Xin Lu
    Citation: Arthritis Research & Therapy 2024 26:158
    Content type: Research Published on:

  34. Equivalent efficacy and comparable pharmacokinetic, immunogenicity, and safety profiles of the biosimilar BAT1806/BIIB800 and reference tocilizumab (TCZ) in participants with moderate-to-severe rheumatoid arth...

    Authors: Xiaomei Leng, Piotr Leszczyński, Slawomir Jeka, Shengyun Liu, Huaxiang Liu, Malgorzata Miakisz, Jieruo Gu, Lali Kilasonia, Mykola Stanislavchuk, Xiaolei Yang, Yinbo Zhou, Qingfeng Dong, Marian Mitroiu, Janet Addison, Mourad F. Rezk and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2024 26:157
    Content type: Research Published on:

  35. Elevated serum immunoglobulin G4 (IgG4) concentrations are one of the characteristic findings in IgG4-related disease (IgG4-RD). This study investigated the frequency of elevated serum IgG4 levels and associat...

    Authors: Shunsuke Tsuge, Hiroshi Fujii, Mami Tamai, Hiromasa Tsujiguchi, Misaki Yoshida, Nobuhiro Suzuki, Yoshinori Takahashi, Akari Takeji, Shigeto Horita, Yuhei Fujisawa, Takahiro Matsunaga, Takeshi Zoshima, Ryo Nishioka, Hiromi Nuka, Satoshi Hara, Yukiko Tani…
    Citation: Arthritis Research & Therapy 2024 26:156
    Content type: Research Published on:

  36. To analyse clinical outcomes of a non-medical switch from originator adalimumab (ADA) to its ABP501 biosimilar (ABP) over 6 months in patients with inflammatory rheumatic musculoskeletal diseases (RMD) in rela...

    Authors: Imke Redeker, Stefan Moustakis, Styliani Tsiami, Xenofon Baraliakos, David Kiefer, Ioana Andreica, Björn Buehring, Jürgen Braun and Uta Kiltz
    Citation: Arthritis Research & Therapy 2024 26:155
    Content type: Research Published on:

  37. Authors: Hermine I Brunner, Grant S Schulert, Alyssa Sproles, Sherry Thornton, Gabriel Vega Cornejo, Jordi Antón, Ruben Cuttica, Michael Henrickson, Ivan Foeldvari, Daniel J Kingsbury, Margarita Askelson, Jinqi Liu, Sumanta Mukherjee, Robert L Wong, Daniel J Lovell, Alberto Martini…
    Citation: Arthritis Research & Therapy 2024 26:154
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2024 26:125

  38. Patients with rheumatoid arthritis (RA) have an increased risk of developing serious infections (SIs) vs. individuals without RA; efforts to predict SIs in this patient group are ongoing. We assessed the abili...

    Authors: Merete Lund Hetland, Anja Strangfeld, Gianluca Bonfanti, Dimitrios Soudis, J. Jasper Deuring and Roger A. Edwards
    Citation: Arthritis Research & Therapy 2024 26:153
    Content type: Research Published on:

  39. Anti-Ro-52 antibodies have been associated with interstitial lung disease (ILD) in various autoimmune diseases. However, their role in ILD among patients with idiopathic inflammatory myopathies (IIMs) is relat...

    Authors: Chia-Tse Weng, Tang-Hsiu Huang, Chun-Hsin Wu and Yuan-Ting Sun
    Citation: Arthritis Research & Therapy 2024 26:152
    Content type: Research Published on:

  40. To investigate the risk factors of renal tubular acidosis (RTA) in patients with primary Sjögren’s syndrome (pSS) and create a personalized nomogram for predicting pSS-RTA patients.

    Authors: Yanzhen Zeng, Runzhi Liu, Shuyi Li, Jingwen Wei, Fei Luo, Yongkang Chen and Dongmei Zhou
    Citation: Arthritis Research & Therapy 2024 26:151
    Content type: Research Published on:

  41. Rheumatoid Arthritis (RA) often exhibits suboptimal treatment response despite early diagnosis and treatment. This study aimed to analyze Early Rheumatoid Arthritis (ERA) synovial biopsies through histology an...

    Authors: Francesco Natalucci, Clément Triaille, Cécile Van Mullem, Tatiana Sokolova, Emilie Sapart, Laurent Meric de Bellefon, Adrien Nzeusseu, Christine Galant, Bernard Lauwerys and Patrick Durez
    Citation: Arthritis Research & Therapy 2024 26:150
    Content type: Research Published on:

  43. We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here, using...

    Authors: Kevin M.-C. Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey, Martha Zeeman, Anne M. Fourie and John A. Hamilton
    Citation: Arthritis Research & Therapy 2024 26:148
    Content type: Research Published on:

  44. Differentiating between degenerative disc disease (DDD), diffuse idiopathic skeletal hyperostosis (DISH), and axial spondyloarthritis (axSpA) represents a diagnostic challenge in patients with low back pain (L...

    Authors: Nelly Ziade, Melanie Udod, Nikolaos Kougkas, Styliani Tsiami and Xenofon Baraliakos
    Citation: Arthritis Research & Therapy 2024 26:147
    Content type: Research Published on:

  45. IL-40 is a novel cytokine associated with autoimmune connective tissue disorders such as rheumatoid arthritis (RA) or Sjögren syndrome. We have previously shown an accumulation of IL-40 in the RA joint and its...

    Authors: L. Andrés Cerezo, A. Navrátilová, M. Kuklová, A. Prokopcová, J. Baloun, T. Kropáčková, D. Veigl, S. Popelka, P. Fulín, R. Ballay, K. Pavelka, J. Vencovský and L. Šenolt
    Citation: Arthritis Research & Therapy 2024 26:146
    Content type: Research Published on:

  46. Adipose tissue has been associated with knee osteoarthritis (KOA) pathogenesis, but the longitudinal changes in adipose tissue with KOA progression have not been carefully evaluated. This study aimed to determ...

    Authors: Kwanghoon Lee, Marina Banuls-Mirete, Alecio F. Lombardi, Alexander I.B. Posis, Eric Y. Chang, Nancy E. Lane and Monica Guma
    Citation: Arthritis Research & Therapy 2024 26:145
    Content type: Research Published on:

  47. To develop an inflammation-related immunohistochemistry marker-based algorithm that confers higher diagnostic ability for idiopathic inflammatory myopathies (IIMs) than IIM-related histopathologic features.

    Authors: Byeongzu Ghang, So Hye Nam, Wonho Choi, Hwa Jung Kim, Jungsun Lee, Doo-Ho Lim, Soo Min Ahn, Ji Seon Oh, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Jinseok Kim, Bin Yoo and Soo Jeong Nam
    Citation: Arthritis Research & Therapy 2024 26:144
    Content type: Research Published on:

  48. To evaluate the efficacy and safety of upadacitinib monotherapy versus methotrexate (MTX) monotherapy over 5 years among MTX-naïve patients with moderately to severely active rheumatoid arthritis (RA) in the l...

    Authors: Ronald van Vollenhoven, Vibeke Strand, Tsutomu Takeuchi, Nilmo Chávez, Pablo Mannucci Walter, Atul Singhal, Jerzy Swierkot, Nasser Khan, Xianwei Bu, Yihan Li, Sara K. Penn, Heidi S. Camp and Jacob Aelion
    Citation: Arthritis Research & Therapy 2024 26:143
    Content type: Research Published on:

  49. Inflammatory rheumatic diseases (IRD) are often associated with interstitial lung disease (ILD). The aim of the present study was to establish a correlation between the findings on HRCT and the immunological b...

    Authors: Tobias Hoffmann, Ulf Teichgräber, Martin Förster, Peter Oelzner, Claus Kroegel, Diane Renz, Tobias Weise, Joachim Böttcher, P. Christian Schulze, Gunter Wolf, Marcus Franz and Alexander Pfeil
    Citation: Arthritis Research & Therapy 2024 26:142
    Content type: Research Published on:

  50. In spondyloarthritides (SpA) and fibromyalgia (FM), patients suffer from generalized pain. The impact of FM on PRO validated in SpA has not been systematically studied.

    Authors: Styliani Tsiami, Piet Dukatz, Maria Gkelaki, Philipp Sewerin, Uta Kiltz and Xenofon Baraliakos
    Citation: Arthritis Research & Therapy 2024 26:141
    Content type: Research Published on:
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Arthritis Research & Therapy

ISSN: 1478-6362

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