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  1. To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant...

    Authors: N. M. Korthagen, E. Houtman, I. Boone, R. Coutinho de Almeida, K. Sivasubramaniyan, R. Mahdad, R. G. H. H Nelissen, Y. F. M. Ramos, M. A Tessari and I. Meulenbelt
    Citation: Arthritis Research & Therapy 2024 26:91
    Content type: Research Published on:

  4. We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients.

    Authors: Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2024 26:87
    Content type: Research Published on:

  5. Little is known about long-term clinical outcomes or urate-lowering (ULT) therapy use following pegloticase discontinuation. We examined ULT use, serum urate (SU), inflammatory biomarkers, and renal function f...

    Authors: Emily E. Holladay, Amy S. Mudano, Fenglong Xie, Jingyi Zhang, Ted R. Mikuls, Brian LaMoreaux, Lissa Padnick-Silver and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2024 26:86
    Content type: Research Published on:

  6. Immunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often developing gastrointestinal and renal involvement and thus contributing to higher mortality. Due to understudied ...

    Authors: Matija Bajželj, Matjaž Hladnik, Rok Blagus, Vesna Jurčić, Ana Markež, Tanya Deniz Toluay, Snežna Sodin-Šemrl, Alojzija Hočevar and Katja Lakota
    Citation: Arthritis Research & Therapy 2024 26:85
    Content type: Research Published on:

  7. We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify potential therapeutic targets.

    Authors: Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin and Hongliang Yu
    Citation: Arthritis Research & Therapy 2024 26:84
    Content type: Research Published on:

  8. Hip and knee osteoarthritis (OA) are highly prevalent worldwide. The guidelines recommend physical activity and education as the core treatments for osteoarthritis. Digital health has the potential to engage p...

    Authors: F. Weber, C. Kloek, S. Stuhrmann, Y. Blum, C. Grüneberg and C. Veenhof
    Citation: Arthritis Research & Therapy 2024 26:83
    Content type: Research Published on:

  9. Previous studies have shown that growing up with rheumatic conditions can fuel dissatisfaction and psychological distress, which in turn affects disease self-management and treatment adherence. Primary objecti...

    Authors: Florian Milatz, Jens Klotsche, Martina Niewerth, Claudia Sengler, Daniel Windschall, Tilmann Kallinich, Frank Dressler, Ralf Trauzeddel, Reinhard W. Holl, Ivan Foeldvari, Normi Brück, Svenja Temming, Toni Hospach, Petra Warschburger, Rainer Berendes, Gabriele Erbis…
    Citation: Arthritis Research & Therapy 2024 26:82
    Content type: Research Published on:

  10. Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo
    Citation: Arthritis Research & Therapy 2024 26:81
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2024 26:74

  11. Our study aimed to provide real-world evidence on the treatment patterns, effectiveness and safety of canakinumab in France in Familial Mediterranean Fever (FMF), Mevalonate Kinase Deficiency (MKD), and Tumor ...

    Authors: Isabelle Koné-Paut, Sophie Georgin-Lavialle, Alexandre Belot, Magali Jover, Mathilde Pouriel, Laure Lacoin, Pascal Pillet and Véronique Hentgen
    Citation: Arthritis Research & Therapy 2024 26:80
    Content type: Research Published on:

  12. Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not fully defined yet. According to previous small case series, the combination of mycophenolat...

    Authors: Corrado Campochiaro, Nicola Farina, Giacomo De Luca, Veronica Batani, Giorgia Trignani, Davide Vignale, Anna Palmisano, Marco Matucci-Cerinic and Lorenzo Dagna
    Citation: Arthritis Research & Therapy 2024 26:79
    Content type: Research Published on:

  13. Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of functional fine-mapping tools such as reporter assays and genome editing. In...

    Authors: Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2024 26:78
    Content type: Research Published on:

  14. Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of o...

    Authors: Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein and Robert B Lochhead
    Citation: Arthritis Research & Therapy 2024 26:77
    Content type: Research Published on:

  15. Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) i...

    Authors: Jiachen Li, Feng Sun, Danxue Zhu, Yuke Hou, Gong Cheng, Ping Wang, Xu Jin, Wenyan Zhou, Xiaolin Sun, Zhanguo Li and Tian Liu
    Citation: Arthritis Research & Therapy 2024 26:76
    Content type: Research Published on:

  16. Treatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensive treatment option for patients with severe forms of systemic sclerosis (SSc). Even th...

    Authors: Ann-Christin Pecher, Reinhild Klein, Ina Koetter, Marieke Wagner, Wichard Vogel, Stefan Wirths, Claudia Lengerke and Joerg Christoph Henes
    Citation: Arthritis Research & Therapy 2024 26:75
    Content type: Research Published on:

  17. Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and several internal organs, including lungs. Macrophages are the main cells i...

    Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo
    Citation: Arthritis Research & Therapy 2024 26:74
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:81

  18. Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of sy...

    Authors: Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies and C. Thomas Appleton
    Citation: Arthritis Research & Therapy 2024 26:73
    Content type: Research Published on:

  20. Transferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we aim to investigate the role of TfR1 in OA progression and its underly...

    Authors: Wenchao Wang, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang and Xingzhi Jing
    Citation: Arthritis Research & Therapy 2024 26:71
    Content type: Research Published on:

  21. Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself.

    Authors: Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe Hässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette and Niek de Vries
    Citation: Arthritis Research & Therapy 2024 26:70
    Content type: Research Published on:

  22. To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease.

    Authors: Mojca Zajc Avramovič, Nataša Toplak, Gašper Markelj, Nina Emeršič and Tadej Avčin
    Citation: Arthritis Research & Therapy 2024 26:69
    Content type: Research Published on:

  23. To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without concomitant Sjögren’s disease (SjD).

    Authors: Lisa Christ, Seraphina Kissling, Axel Finckh, Benjamin A. Fisher, Sabine Adler, Britta Maurer, Burkhard Möller and Florian Kollert
    Citation: Arthritis Research & Therapy 2024 26:68
    Content type: Research Published on:

  24. To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia (SLE-TP).

    Authors: Jun Li, Liying Peng, Lijun Wu, Yufang Ding, Xinwang Duan, Jian Xu, Wei Wei, Zhen Chen, Cheng Zhao, Min Yang, Nan Jiang, Shangzhu Zhang, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng…
    Citation: Arthritis Research & Therapy 2024 26:67
    Content type: Research Published on:

  25. CRISPR-Cas9-based genome engineering represents a powerful therapeutic tool for cartilage tissue engineering and for understanding molecular pathways driving cartilage diseases. However, primary chondrocytes a...

    Authors: Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F. Bruhin, Alexis Laurent, Lee Ann Applegate, Marcy Zenobi-Wong and Goncalo Barreto
    Citation: Arthritis Research & Therapy 2024 26:66
    Content type: Research Published on:

  26. Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnan...

    Authors: Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg, Tansim Akhter, Dag Leonard, Lars Rönnblom, Sofia Pihl, Muna Saleh, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A. Bengtsson, Estelle Trysberg, Maria Majczuk Sennström, Agneta Zickert…
    Citation: Arthritis Research & Therapy 2024 26:65
    Content type: Research Published on:

  27. Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to...

    Authors: Chen Cheng, Hao Yang, Chan Yang, Juan Xie, Jinshen Wang, Luping Cheng, Jianfu He, Honglian Li, Haoxing Yuan, Fangfang Guo, Minmin Li and Shuwen Liu
    Citation: Arthritis Research & Therapy 2024 26:64
    Content type: Research Published on:

  28. Remission is a key treatment target in systemic lupus erythematosus (SLE) management. Given the direct correlation between lupus flares and elevated risks of adverse pregnancy outcomes (APOs), securing remissi...

    Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada
    Citation: Arthritis Research & Therapy 2024 26:63
    Content type: Research Published on:

  29. Primary Sjogren’s syndrome (pSS) is a complex autoimmune disease featuring damage to salivary and lacrimal glands, with the possibility of manifestations across multiple organs. Antibody-producing B cells have...

    Authors: Ling Chang, Zihan Zheng, Yiwen Zhou, Kun Liu, Yinong Li, Bing Zhong, Zihua Zhao, Chengshun Chen, Can Qian, Qingshan Ni, Qinghua Zou, Yuzhang Wu, Jingyi Li and Liyun Zou
    Citation: Arthritis Research & Therapy 2024 26:62
    Content type: Research Published on:

  30. Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient’s response to these therapies. Prostanoi...

    Authors: Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed and Per-Johan Jakobsson
    Citation: Arthritis Research & Therapy 2024 26:61
    Content type: Research Published on:

  32. The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block.

    Authors: Na Li, Liufu Cui, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Gary Tse, Nan Zhang, Xuemei Yang, Wenqi Xu, Shouling Wu and Tong Liu
    Citation: Arthritis Research & Therapy 2024 26:59
    Content type: Research Published on:

  33. The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with the nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants.

    Authors: Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu and Min Shen
    Citation: Arthritis Research & Therapy 2024 26:58
    Content type: Research Published on:

  34. Patients with Rheumatoid Arthritis (RA) have a higher prevalence of comorbidities compared to the general population. However, the implications of multimorbidity on therapeutic response and treatment retention...

    Authors: Jerusalem Calvo-Gutiérrez, Clementina López-Medina, Lucía Otero-Varela, Alejandro Escudero-Contreras, Rafaela Ortega-Castro, Lourdes Ladehesa-Pineda, Cristina Campos, Pilar Bernabeu-Gonzalvez, Ana Pérez-Gómez, Alicia García-Dorta, Dolores Ruiz-Montesino, Manuel Pombo-Suarez, Inmaculada Ros-Vilamajo, Fernando Sánchez-Alonso and Isabel Castrejón
    Citation: Arthritis Research & Therapy 2024 26:57
    Content type: Research Published on:

  35. Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes disability worldwide. Exosomes released by fibroblast-like synoviocytes in RA (RA-FLSs-Exos) play a role in the development of RA, and ci...

    Authors: Guoqing Li, Yuxuan Fang, Nan Xu, Yimin Ding and Dan Liu
    Citation: Arthritis Research & Therapy 2024 26:56
    Content type: Research Published on:

  36. IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obli...

    Authors: Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata, Masahiro Kiuchi, Kota Kokubo, Tomohisa Iinuma, Takahiro Sugiyama, Toyoyuki Hanazawa, Kiyoshi Hirahara, Kei Ikeda and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2024 26:55
    Content type: Research Published on:

  37. Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus ne...

    Authors: Peter M. Izmirly, Mimi Y. Kim, Philip M. Carlucci, Katherine Preisinger, Brooke Z. Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall’Era, Kenneth Kalunian, Andrea Fava, H. Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, Betty Diamond…
    Citation: Arthritis Research & Therapy 2024 26:54
    Content type: Research Published on:

  38. Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they re...

    Authors: Akshay Pandey, Mamta Singla, Ana Geller, Stuart B. Goodman and Nidhi Bhutani
    Citation: Arthritis Research & Therapy 2024 26:53
    Content type: Research Published on:

  39. Henoch–Schönlein purpura (HSP) is the most common immunoglobulin A-mediated systemic vasculitis in childhood. We studied immune dysregulation in HSP by analyzing regulatory T (Treg), T helper 3 (Th3), and regu...

    Authors: Anne Filleron, Renaud Cezar, Marc Fila, Nastassja Protsenko, Kathleen Van Den Hende, Eric Jeziorski, Bob Occean, Thierry Chevallier, Pierre Corbeau and Tu Anh Tran
    Citation: Arthritis Research & Therapy 2024 26:52
    Content type: Research Published on:

  40. Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of c...

    Authors: Liam J. O’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema and Hani El-Gabalawy
    Citation: Arthritis Research & Therapy 2024 26:51
    Content type: Correspondence Published on:

  41. Capacity to work is impacted by psoriatic arthritis (PsA). Our objective was to describe the course of work productivity and leisure activity in patients with PsA treated with biologic (b) and targeted synthet...

    Authors: Laure Gossec, Brittany Humphries, Megan Rutherford, Vanessa Taieb, Damon Willems and William Tillett
    Citation: Arthritis Research & Therapy 2024 26:50
    Content type: Review Published on:

  42. We report long-term, end-of-study program safety outcomes from 25 randomized clinical trials (RCTs) in adult patients with psoriasis (PsO), psoriatic arthritis (PsA), or axial spondyloarthritis (axSpA) [includ...

    Authors: Atul Deodhar, Andrew Blauvelt, Mark Lebwohl, Meghan Feely, Andris Kronbergs, Nadezhda Eberhart, Danting Zhu, Elsa Inman, Elsie Grace, Thorsten Holzkaemper, Proton Rahman, Helena Marzo-Ortega, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb and Sergio Schwartzman
    Citation: Arthritis Research & Therapy 2024 26:49
    Content type: Research Published on:

  43. Previous studies have shown conflicting evidence regarding the incidence of cancer in patients with systemic lupus erythematosus (SLE) compared with that in healthy individuals. Calcineurin inhibitors (CNIs) s...

    Authors: Kunihiro Ichinose, Shuntaro Sato, Takashi Igawa, Momoko Okamoto, Ayuko Takatani, Yushiro Endo, Sosuke Tsuji, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Nobuyuki Yajima…
    Citation: Arthritis Research & Therapy 2024 26:48
    Content type: Research Published on:

  44. Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been e...

    Authors: Daeun Kim, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Junghyun Jung and Wonhee Jang
    Citation: Arthritis Research & Therapy 2024 26:47
    Content type: Research Published on:

  45. Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pe...

    Authors: Mira Sandersfeld, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz and Christoph Daniel
    Citation: Arthritis Research & Therapy 2024 26:46
    Content type: Research Published on:

  46. Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single-nucleotide polymorphisms (SNPs) have been identified as associated with both alcohol consumption and serum urate or gout in sep...

    Authors: Min H Chuah, Megan P Leask, Ruth K Topless, Gregory D Gamble, Nicholas A Sumpter, Lisa K Stamp, Tony R Merriman and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2024 26:45
    Content type: Research Published on:

  47. Machine learning models can support an individualized approach in the choice of bDMARDs. We developed prediction models for 5 different bDMARDs using machine learning methods based on patient data derived from...

    Authors: Dubravka Ukalovic, Burkhard F. Leeb, Bernhard Rintelen, Gabriela Eichbauer-Sturm, Peter Spellitz, Rudolf Puchner, Manfred Herold, Miriam Stetter, Vera Ferincz, Johannes Resch-Passini, Jochen Zwerina, Marcus Zimmermann-Rittereiser and Ruth Fritsch-Stork
    Citation: Arthritis Research & Therapy 2024 26:44
    Content type: Research Published on:

  48. Sjögren’s disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and ...

    Authors: Mehrnaz Maleki-Fischbach, Liudmila Kastsianok, Matthew Koslow and Edward D. Chan
    Citation: Arthritis Research & Therapy 2024 26:43
    Content type: Review Published on:

  49. Obese RA patients have higher disease activity scores (DAS). Previous research showed that obese RA patients have higher tender joint count (TJC) and VAS general health. However, it remains unclear whether DAS...

    Authors: N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil and H. W. van Steenbergen
    Citation: Arthritis Research & Therapy 2024 26:42
    Content type: Research Published on:

  50. Authors: Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao and Jun Tang
    Citation: Arthritis Research & Therapy 2024 26:39
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:206

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Arthritis Research & Therapy

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