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  1. Although cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an animal model of cervical disc degeneration and discogenic neck pain i...

    Authors: Jie Li, Hui Li, Yilei Chen, Dikai Bei, Bao Huang, Kaifeng Gan, Peiming Sang, Junhui Liu, Zhi Shan, Jian Chen, Fengdong Zhao and Binhui Chen
    Citation: Arthritis Research & Therapy 2024 26:41
    Content type: Research Published on:

  3. Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is a common clinical manifestation. In SLE patients, cerebral function is a more sensitive predictor of central nervous system damage, and abn...

    Authors: Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2024 26:38
    Content type: Research Published on:

  4. The etiology of giant cell arteritis (GCA) and its predictors are incompletely understood. Previous studies have indicated reduced risk of future development of GCA in individuals with obesity and/or diabetes ...

    Authors: Karin Wadström, Lennart T. H. Jacobsson, Aladdin J. Mohammad, Kenneth J. Warrington, Eric L. Matteson and Carl Turesson
    Citation: Arthritis Research & Therapy 2024 26:37
    Content type: Research Published on:

  5. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This ...

    Authors: Jianhua Zhang, Hao Cai, Weiwei Sun, Weijie Wu, Yunyi Nan, Yingchen Ni, Xinyuan Wu, Minhao Chen, Hua Xu and Youhua Wang
    Citation: Arthritis Research & Therapy 2024 26:36
    Content type: Research Published on:

  6. Whether rheumatoid arthritis patients have an increased risk of cervical cancer remains controversial, and further research is needed on this clinical question. This study aims to investigate the association b...

    Authors: Minxian Xu, Huan Chen, Tao Tan, Kaihong Xie, Hui Xie and Qing Li
    Citation: Arthritis Research & Therapy 2024 26:35
    Content type: Research Published on:

  7. Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan
    Citation: Arthritis Research & Therapy 2024 26:34
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:151

  8. Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation in primary osteoarthritis (OA), a common age-associated joint disease. EV subpopulati...

    Authors: Anne-Mari Mustonen, Mari Palviainen, Laura Säisänen, Lauri Karttunen, Sylvain Tollis, Amir Esrafilian, Jusa Reijonen, Petro Julkunen, Pia R-M Siljander, Heikki Kröger, Jussi Mäki, Jari Arokoski and Petteri Nieminen
    Citation: Arthritis Research & Therapy 2024 26:33
    Content type: Research Published on:

  9. PD-1 is an immune checkpoint on T cells, and interventions to block this receptor result in T cell activation and enhanced immune response to tumors and pathogens. Reciprocally, despite a decade of research, a...

    Authors: Johanna Straube, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Yevgeniya Gartshteyn, Brian S. Henick, Matthew A. Dragovich and Adam Mor
    Citation: Arthritis Research & Therapy 2024 26:32
    Content type: Research Published on:

  10. Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the ...

    Authors: Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng and Richard Bucala
    Citation: Arthritis Research & Therapy 2024 26:31
    Content type: Research Published on:

  11. To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relation...

    Authors: Shirley P. Yu, Leticia A. Deveza, Virginia B. Kraus, Morten Karsdal, Anne-Christine Bay-Jensen, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Christoph Ladel, Venkatesha Bhagavath and David J. Hunter
    Citation: Arthritis Research & Therapy 2024 26:30
    Content type: Research Published on:

  12. Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonar...

    Authors: Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo and Xiaoxia Zuo
    Citation: Arthritis Research & Therapy 2024 26:29
    Content type: Research Published on:

  13. To early recognise and improve the prognosis of children systemic lupus erythematosus (cSLE)-associated pancreatitis by summarising and analysing clinical features and prognosis data from 12 cases.

    Authors: Dan Zhang, Jianming Lai, Gaixiu Su, Jia Zhu, Min, Kang, Ming Li, Yingjie Xu and Li Meng
    Citation: Arthritis Research & Therapy 2024 26:28
    Content type: Research Published on:

  14. Dermatomyositis is an idiopathic inflammatory myopathy characterised by rashes and progressive muscle weakness. The recent ProDERM (Progress in DERMatomyositis) study is the first large randomised, placebo-con...

    Authors: Rohit Aggarwal, Joachim Schessl, Christina Charles-Schoeman, Zsuzsanna Bata-Csörgő, Mazen M. Dimachkie, Zoltan Griger, Sergey Moiseev, Chester V. Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi and Todd Levine
    Citation: Arthritis Research & Therapy 2024 26:27
    Content type: Research Published on:

  15. Primary Sjögren's syndrome (pSS) is an autoimmune condition that causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS patients with EGM have a worse prognosis than those with o...

    Authors: Jingwei Hong, Hui Cheng, Ping Wang, Yanzhi Wu, Saisai Lu, Yan Zhou, Xiao bing Wang and Xiaofang Zhu
    Citation: Arthritis Research & Therapy 2024 26:26
    Content type: Research Published on:

  16. Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent pr...

    Authors: Kwanghoon Lee, Soheil Niku, Sonya J. Koo, Ernest Belezzuoli and Monica Guma
    Citation: Arthritis Research & Therapy 2024 26:25
    Content type: Review Published on:

  17. Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological fact...

    Authors: Yuchang Fei, Huan Yu, Yulun Wu and Shanshan Gong
    Citation: Arthritis Research & Therapy 2024 26:24
    Content type: Research Published on:

  18. Involvement of B cells in the pathogenesis of rheumatoid arthritis (RA) is supported by the presence of disease-specific autoantibodies and the efficacy of treatment directed against B cells. B cells that expr...

    Authors: Katrin Thorarinsdottir, Sarah McGrath, Kristina Forslind, Monica Leu Agelii, Anna-Karin Hultgård Ekwall, Lennart T. H. Jacobsson, Anna Rudin, Inga-Lill Mårtensson and Inger Gjertsson
    Citation: Arthritis Research & Therapy 2024 26:23
    Content type: Research Published on:

  20. Patients with rheumatoid arthritis (RA) showed impaired immune tolerance characterized by reduced follicular regulatory T (Tfr) cells, and they also exhibited altered gut microbiotas and their metabolites in R...

    Authors: Ruihe Wu, Dongming Wang, Liyun Cheng, Rui Su, Baochen Li, Chunxue Fan, Chong Gao and Caihong Wang
    Citation: Arthritis Research & Therapy 2024 26:21
    Content type: Research Published on:

  21. Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalanc...

    Authors: Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang and Dechun Geng
    Citation: Arthritis Research & Therapy 2024 26:20
    Content type: Research Published on:

  22. Despite existing extensive literature, a comprehensive and clinically relevant classification system for osteoarthritis (OA) has yet to be established. In this study, we aimed to further characterize four knee...

    Authors: Joan Calvet, Antoni Berenguer-Llergo, Cristóbal Orellana, María García-Manrique, Menna Rusiñol, Silvia Garcia-Cirera, Maria Llop, Marta Arévalo, Alba Garcia-Pinilla, Carlos Galisteo, Cristina Aymerich, Rafael Gómez, Alejandra Serrano, Anna Carreras and Jordi Gratacós
    Citation: Arthritis Research & Therapy 2024 26:19
    Content type: Research Published on:

  23. Inflammatory arthritis encompasses a group of immune-mediated diseases characterized by chronic joint inflammation. Despite having pathogenic mechanisms in common, the prognosis of rheumatoid arthritis (RA), p...

    Authors: Ana Belén Azuaga, Andrea Cuervo, Raquel Celis, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Virginia Ruiz-Esquide, José A. Gómez-Puerta, Raimon Sanmartí and Julio Ramírez
    Citation: Arthritis Research & Therapy 2024 26:18
    Content type: Research Published on:

  24. Variations in bone morphology in patients with hip osteoarthritis (HOA) can be broadly categorized into three types: atrophic, normotrophic, and hypertrophic. Despite the investigations examining clinical elem...

    Authors: Yang Yang, Hideyuki Koga, Yusuke Nakagawa, Tomomasa Nakamura, Hiroki Katagiri, Ryohei Takada, Mai Katakura, Kunikazu Tsuji, Ichiro Sekiya and Kazumasa Miyatake
    Citation: Arthritis Research & Therapy 2024 26:17
    Content type: Research Published on:

  25. Advances in rheumatoid arthritis (RA) treatment, highlighted by biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), have altered the paradigm of RA treatment in...

    Authors: Takayuki Fujii, Koichi Murata, Hideo Onizawa, Akira Onishi, Masao Tanaka, Kosaku Murakami, Kohei Nishitani, Moritoshi Furu, Ryu Watanabe, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Tsuneyo Mimori, Akio Morinobu and Shuichi Matsuda
    Citation: Arthritis Research & Therapy 2024 26:16
    Content type: Research Published on:

  26. Tacrolimus is one of the major treatment options for systemic lupus erythematosus (SLE) and is considered to be a pregnancy-compatible medication. Since little is known about tacrolimus safety during pregnancy...

    Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada
    Citation: Arthritis Research & Therapy 2024 26:15
    Content type: Research Published on:

  27. A consistent connection has been increasingly reported between rheumatoid arthritis (RA), insulin resistance (IR), and type 2 diabetes (T2D). The β-cell apoptosis induced by pro-inflammatory cytokines, which c...

    Authors: Claudia Di Muzio, Ilenia Di Cola, Azadeh Shariat Panahi, Francesco Ursini, Annamaria Iagnocco, Roberto Giacomelli, Paola Cipriani and Piero Ruscitti
    Citation: Arthritis Research & Therapy 2024 26:14
    Content type: Research Published on:

  28. To investigate the usefulness of 18F-FDG PET-CT for assessing large-vessel (LV) involvement in patients with suspected giant cell arteritis (GCA) and a negative temporal artery biopsy (TAB).

    Authors: Javier Narváez, Paula Estrada, Paola Vidal-Montal, Iván Sánchez-Rodríguez, Aida Sabaté-Llobera, Joan Miquel Nolla and Montserrat Cortés-Romera
    Citation: Arthritis Research & Therapy 2024 26:13
    Content type: Research Published on:

  29. Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degene...

    Authors: Kyle Kuchynsky, Patrick Stevens, Amy Hite, William Xie, Khady Diop, Shirley Tang, Maciej Pietrzak, Safdar Khan, Benjamin Walter and Devina Purmessur
    Citation: Arthritis Research & Therapy 2024 26:12
    Content type: Research Published on:

  30. The biological function of Acanthopanax sessiliflorus Harm (ASH) has been investigated on various diseases; however, the effects of ASH on arthritis have not been investigated so far. This study investigates t...

    Authors: Dahye Kim, Yunji Heo, Mangeun Kim, Godagama Gamaarachchige Dinesh Suminda, Umar Manzoor, Yunhui Min, Minhye Kim, Jiwon Yang, Youngjun Park, Yaping Zhao, Mrinmoy Ghosh and Young-Ok Son
    Citation: Arthritis Research & Therapy 2024 26:11
    Content type: Research Published on:

  31. Overlapping cases of systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are rare and have not yet been fully proven to be accidental or have a common genetic basis.

    Authors: Linyong Wu, Songhua Li, Chaojun Wu, Shaofeng Wu, Yan Lin and Dayou Wei
    Citation: Arthritis Research & Therapy 2024 26:10
    Content type: Research Published on:

  32. Anti-melanoma differentiation-associated gene five antibody positive (MDA5+) dermatomyositis (DM) is significantly associated with rapidly progressive interstitial lung disease (RP-ILD). Early detection of RP-ILD...

    Authors: Yulu Qiu, Xiaoke Feng, Chang Liu, Yumeng Shi, Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, Fang Wang and Wenfeng Tan
    Citation: Arthritis Research & Therapy 2024 26:9
    Content type: Research Published on:

  33. Autoimmune congenital heart block (ACHB) is a passively acquired immune-mediated disease characterized by the presence of maternal antibodies against components of the Ro/SSA and La/SSB ribonucleoprotein compl...

    Authors: Ying Huang, Jialin Deng, Jinghua Liu, Fangyuan Yang and Yi He
    Citation: Arthritis Research & Therapy 2024 26:8
    Content type: Review Published on:

  34. NAT10 is the firstly recognized RNA acetyltransferase that participates in multiple cellular biological processes and human disease. However, the role of N-acetyltransferase 10 (NAT10) in ankylosing spondyliti...

    Authors: Qing Luo, Juxiang Zhu, Shiqian Wang, Peng fu, Biqi Fu, Zikun Huang and Junming Li
    Citation: Arthritis Research & Therapy 2024 26:7
    Content type: Research Published on:

  35. Hypertrophic cranial pachymeningitis (HCP) is uncommon but a poorly understood complication of granulomatosis with polyangiitis (GPA).

    Authors: Yiran Chen, Lijuan Gou, Li Wang, Min Qian, Qingjun Wu, Wenjie Zheng, Mengtao Li, Xiaofeng Zeng and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2024 26:6
    Content type: Research Published on:

  36. There is mounting proof that rheumatoid arthritis (RA) and cognitive decline are related. These studies, however, have not all been uniform, and others have not discovered such a correlation. It is essential t...

    Authors: Lincheng Duan, Shiyin Li, Haoming Li, Yue Shi, Xiaolong Xie and Yue Feng
    Citation: Arthritis Research & Therapy 2024 26:5
    Content type: Research Published on:

  37. Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is a group of illnesses that cause inflammation and alterations to small vessels in the body. Some of the most common and detrimental mani...

    Authors: Megan M. Sullivan, Andy Abril, Nabeel Aslam, Colleen T. Ball and Florentina Berianu
    Citation: Arthritis Research & Therapy 2024 26:4
    Content type: Research Published on:

  38. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation in multiple articular joints, causing pain, joint damage, and loss of joint function. Despite the successful development ...

    Authors: Christian S. Thudium, Peder Frederiksen, Morten A. Karsdal and Anne-Christine Bay-Jensen
    Citation: Arthritis Research & Therapy 2024 26:3
    Content type: Research Published on:

  39. This study aims to investigate the potential anti-inflammatory effects of exosomes engineered to carry super-repressor IκB (Exo-srIκB), an exosome-based NF-κB inhibitor, in the context of RA.

    Authors: Hae-In Lee, Min-Joo Ahn, Jae-Kwang Yoo, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Moon-Ju Kim, Yu Jeong Lee, Hyun Hee Jang, Seung Cheol Shim, Eun Jeong Won, Cheolhyoung Park, Chulhee Choi and Tae-Jong Kim
    Citation: Arthritis Research & Therapy 2024 26:2
    Content type: Research Published on:

  40. The biological mechanisms underlying the differential response to abatacept in patients with rheumatoid arthritis (RA) are unknown. Here, we aimed to identify cellular, transcriptomic, and proteomic features t...

    Authors: Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, Shuichi Matsuda, Fumihiko Matsuda, Akio Morinobu and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2024 26:1
    Content type: Research Published on:

  42. Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages. While macrophages play a pivotal role in the in...

    Authors: Changchuan Li, Zhuji Ouyang, Yuhsi Huang, Sipeng Lin, Shixun Li, Jing Xu, Taihe Liu, Jionglin Wu, Peidong Guo, Zhong Chen, Haoyu Wu and Yue Ding
    Citation: Arthritis Research & Therapy 2023 25:249
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:22

  43. Lupus mesenteric vasculitis (LMV) as initial presentation is rare, especially in childhood-onset systemic lupus erythematosus (cSLE). It is a critical complication of lupus. At present, the research on cSLE wi...

    Authors: Jia Zhu, Jianming Lai, Xiaohui Liu, Xue Zhao, Ran Tao, Min Kang, Xiaolan Huang, Li Wang, Fengqi Wu, Xiaoping Pan and Gaixiu Su
    Citation: Arthritis Research & Therapy 2023 25:248
    Content type: Research Published on:

  44. Exogenously providing engineered Uox with enhanced half-life is one of the important urate-lowering treatments for gout. The potential of PAT101, a recombinant human albumin (rHA)-conjugated variant, was evalu...

    Authors: Jeonghaeng Cho, Byungseop Yang, Jae Hun Lee, Hyunwoo Kim, Hyeongseok Kim, Eun Byeol Go, Dong-ho Bak, Su Jin Park, Inchan Kwon, Jong-il Choi and Kyunghee Lee
    Citation: Arthritis Research & Therapy 2023 25:247
    Content type: Research Published on:

  45. Rheumatoid arthritis (RA) is a chronic autoimmune disease with complex causes and recurrent attacks that can easily develop into chronic arthritis and eventually lead to joint deformity. Our study aims to eluc...

    Authors: Congcong Jian, Lingli Wei, Tong Wu, Shilin Li, Tingting Wang, Jianghua Chen, Shengjia Chang, Jie Zhang, Binhan He, Jianhong Wu, Jiang Su, Jing Zhu, Min Wu, Yan Zhang and Fanxin Zeng
    Citation: Arthritis Research & Therapy 2023 25:246
    Content type: Research Published on:

  46. This study investigated the clinical implications of peripheral eosinophil count at diagnosis in estimating cross-sectional antineutrophil cytoplasmic antibody-associated vasculitis (AAV) activity and predicti...

    Authors: Jang Woo Ha, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee
    Citation: Arthritis Research & Therapy 2023 25:245
    Content type: Research Published on:

  47. The vasoactive neuropeptide calcitonin gene-related peptide alpha (αCGRP) enhances nociception in primary knee osteoarthritis (OA) and has been shown to disrupt cartilage and joint integrity in experimental rh...

    Authors: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
    Citation: Arthritis Research & Therapy 2023 25:244
    Content type: Research Published on:

  48. Wilforine (WFR) is a monomeric compound of the anti-RA plant Tripterygium wilfordii Hook. f. (TwHF). Whether WFR has anti-RA effect, its molecular mechanism has not been elucidated.

    Authors: Yurong Huang, Yanhui Peng, Hui Li, Chen Li, Yajie Wu, Xiaomei Wang, Jun Chang and Chenggui Miao
    Citation: Arthritis Research & Therapy 2023 25:243
    Content type: Research Published on:

  49. To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design.

    Authors: Yudun Qu, Shibo Chen, Mengling Han, Ziqi Gu, Yujie Zhang, Tianxiang Fan, Muhui Zeng, Guangfeng Ruan, Peihua Cao, Qian Yang, Changhai Ding, Yan Zhang and Zhaohua Zhu
    Citation: Arthritis Research & Therapy 2023 25:242
    Content type: Research Published on:

  50. While xanthine oxidase inhibitors target uric acid production, renal urate underexcretion is the predominant subtypes in gout. This study was to compare treatment response to the XOI febuxostat in a gout cohor...

    Authors: Han Qi, Mingshu Sun, Robert Terkeltaub, Xiaomei Xue, Xinde Li, Lingling Cui, Yuwei He, Fei Yan, Ruixia Sun, Ying Chen, Zhaotong Jia, Xiaoyu Cheng, Lidan Ma, Tian Liu, Nicola Dalbeth and Changgui Li
    Citation: Arthritis Research & Therapy 2023 25:241
    Content type: Research Published on:
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Arthritis Research & Therapy

ISSN: 1478-6362

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