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  1. Systemic lupus erythematosus (SLE) patients, with or without neuropsychiatric SLE (NPSLE), exhibit greater neuronal impairment compared to healthy individuals in terms of neuronal damage, magnet resonance imag...

    Authors: Kristoffer A. Zervides, Elsa Grenmyr, Shorena Janelidze, Petrus Linge, Jessika Nystedt, Petra C. Nilsson, Pia C. Sundgren, Oskar Hansson, Anders A. Bengtsson and Andreas Jönsen
    Citation: Arthritis Research & Therapy 2025 27:60
    Content type: Research Published on:

  2. At present, there are no data on the relationship between colchicine dose and weight in patients with Familial Mediterranean Fever (FMF). We aimed at describing the daily colchicine dose in a cohort of FMF pat...

    Authors: Ilenia Di Cola, Alessandra Bartoli, Léa Savey, Fatima Bensalek, Marion Delplanque, Rim Bourguiba, Zohra Aknouche, Isabelle Kone-Paut, Linda Rossi-Semerano, Isabelle Melki, Brigitte Bader-Meunier, Bénédicte Neven, Pierre Quartier, Guilaine Boursier, Laurence Cuisset, Gilles Grateau…
    Citation: Arthritis Research & Therapy 2025 27:59
    Content type: Correspondence Published on:

  3. Systemic sclerosis (SSc) is a rare autoimmune disease characterized by microvasculopathy, autoantibody production, and fibrosis of the skin and internal organs. Disrupted collagen turnover in SSc leads to exce...

    Authors: Yi He, Jannie M B Sand, Satoshi Kubo, Naoaki Ohkubo, Yusuke Miyazaki, Morten Karsdal, Yoshiya Tanaka and Anne-Christine Bay-Jensen
    Citation: Arthritis Research & Therapy 2025 27:58
    Content type: Research Published on:

  5. Conventional treatments for Raynaud’s phenomenon (RP) often show limited effectiveness due to their inability to address both vascular and inflammatory aspects. This study evaluates the combination of high-den...

    Authors: Chengliang Deng, Xin Liu, Miaomiao Wei, Bihua Wu, Tianhua Zhang, Shune Xiao, Peiru Min and Yixin Zhang
    Citation: Arthritis Research & Therapy 2025 27:56
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2025 27:92

  6. Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in the aorta of TAK patients is c...

    Authors: Na Gao, He Tang, Taotao Li, Yi Yang, Honglei Zhao, Longfei Wang, Yanqiu Guo, Bokang Qiao and Lili Pan
    Citation: Arthritis Research & Therapy 2025 27:55
    Content type: Research Published on:

  7. Quercetagetin, a flavonoid derived from the natural herb Flos eriocauli, is used in traditional Chinese medicine for its fire-purging (anti-inflammation) and wind-expelling (pain-alleviating) properties. Howev...

    Authors: Haojue Wang, Tao Yuan, Jingpeng Wang, Dengju Li, Wayne Yuk-wai Lee, Ziqing Li and Shui Sun
    Citation: Arthritis Research & Therapy 2025 27:54
    Content type: Research Published on:

  8. To evaluate circulating levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in patients with dermatomyositis (DM) and DM associated interstitial lung disease (...

    Authors: Sangmee Sharon Bae, Ani Shahbazian, Jennifer Wang, Daniela Markovic, Tiffany De Leon, Yuna Lee, Srinivasa T. Reddy and Christina Charles-Schoeman
    Citation: Arthritis Research & Therapy 2025 27:53
    Content type: Research Published on:

  9. While targeting the interleukin-6 receptor (IL-6R) through the use of sarilumab (SAR) or tocilizumab (TCZ) has become a major therapeutic approach for rheumatoid arthritis (RA), direct comparisons between IL-6...

    Authors: Akira Onishi, Masao Tanaka, Takayuki Fujii, Koichi Murata, Kosaku Murakami, Motomu Hashimoto, Ryu Watanabe, Yuji Nozaki, Chisato Ashida, Wataru Yamamoto, Hirotaka Yamada, Sho Sendo, Kosuke Ebina, Hidehiko Makino, Yonsu Son, Yumiko Wada…
    Citation: Arthritis Research & Therapy 2025 27:52
    Content type: Research Published on:

  10. Osteoarthritis (OA) is the most common form of joint disease. Currently, OA treatment is limited to controlling symptoms. Our previous study showed that stromal cell-derived factor 1 (SDF-1) delayed the progre...

    Authors: Yanping Zhao, Dan Lin, Xiaoying Zhu, Jingyao Yan, Yan Liang, Yanli Wang, Tianqi Dai, Zhiyi Zhang and Shuya Wang
    Citation: Arthritis Research & Therapy 2025 27:51
    Content type: Research Published on:

  11. Idiopathic inflammatory myopathies (IIM) are characterized by chronic inflammation, endothelial dysfunction, and muscle tissue mitochondrial defect, leading to the local oxidative stress response. However, dat...

    Authors: Anna Mikołajczyk-Korona, Radosław Dziedzic, Krzysztof Wójcik, Magdalena Olchawa, Tadeusz Sarna, Jakub Pięta, Bogdan Jakiela, Lech Zaręba, Jan G. Bazan, Daniel P. Potaczek, Joanna Kosałka-Węgiel, Mateusz Socha, Piotr Kuszmiersz, Agnieszka Padjas and Stanisława Bazan-Socha
    Citation: Arthritis Research & Therapy 2025 27:50
    Content type: Research Published on:

  12. We aimed to investigate the involvement of the classical/lectin complement pathway in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by exploring the complement activation fragment C4d...

    Authors: Anna Juto, Myriam Martin, Albin Björk, Leonid Padyukov, Caroline Grönwall, Aleksandra Antovic, Annette Bruchfeld, Iva Gunnarsson and Anna M. Blom
    Citation: Arthritis Research & Therapy 2025 27:49
    Content type: Research Published on:

  13. Low levels of vitamin D have been associated with several autoimmune diseases. A growing body of evidence supports the association of vitamin D with skeletal muscle damage, regeneration, and energy and lipid m...

    Authors: Lucia Vernerová, Martina Vokurková, Nikoleta Alchus Laiferová, Michal Nemec, Maja Špiritović, Oksana Mytiai, Sabína Oreská, Martin Klein, Kateřina Kubínová, Veronika Horváthová, Tereza Kropáčková, László Wenchich, Michal Tomčík, Jozef Ukropec, Barbara Ukropcová and Jiří Vencovský
    Citation: Arthritis Research & Therapy 2025 27:48
    Content type: Research Published on:

  14. Extracorporeal shockwave therapy (ESWT) is widely used to treat musculoskeletal diseases, but its impact on adolescents with unhealed epiphyseal plates is concerning. It remains unclear whether ESWT applied to...

    Authors: Shun-Wun Jhan, Kuan-Ting Wu, Wen-Yi Chou, Jeng-Wei Chen, Ka-Kit Siu, Wen-Chiung Huang, Ching-Jen Wang and Jai-Hong Cheng
    Citation: Arthritis Research & Therapy 2025 27:47
    Content type: Research Published on:

  15. Despite significant therapeutic advances in psoriatic arthritis (PsA), many patients do not achieve remission and cycle through multiple biologic (b)- or targeted synthetic (ts)- DMARDs. Identifying the underl...

    Authors: Rebecca H. Haberman, Kyra Chen, Catherine Howe, Seungha Um, Adamary Felipe, Brianna Fu, Stephanie Eichman, Margaret Coyle, Eileen Lydon, Andrea L. Neimann, Soumya M. Reddy, Samrachana Adhikari and Jose U. Scher
    Citation: Arthritis Research & Therapy 2025 27:46
    Content type: Research Published on:

  17. The role of long non-coding RNAs (lncRNAs) and their nearby messenger RNAs (mRNAs) in systemic lupus erythematosus (SLE) pathogenesis is not well understood.

    Authors: Tao Liu, Mingyue Yang, Xiunan Feng, Xiaojuan Zou, Ying Xia, Lu Chen, Zixin Gao, Ling Zhao and Xiaosong Wang
    Citation: Arthritis Research & Therapy 2025 27:44
    Content type: Research Published on:

  18. This study aimed to investigate the role and mechanism of the Akt2 pathway in different stages of anterior disc displacement (ADD)-induced temporomandibular joint osteoarthritis (TMJOA).

    Authors: Shi-Yang Feng, Meng-Nan Cao, Chen-Chen Gao, Yi-Xin Li, Jie Lei and Kai-Yuan Fu
    Citation: Arthritis Research & Therapy 2025 27:43
    Content type: Research Published on:

  19. The aim of this study was to provide an in-depth longitudinal locomotor and structural characterisation of the collagenase-induced osteoarthritis (CIOA) mouse model, using the most relevant and up-to-date non-...

    Authors: Anne-Laure Mausset-Bonnefont, Karine Toupet, Christian Jorgensen and Danièle Noël
    Citation: Arthritis Research & Therapy 2025 27:42
    Content type: Research Published on:

  20. To determine differences in the blood innate gene expression signatures of systemic lupus erythematosus (SLE) patients across various organ manifestations and disease activity, with a focus on lupus nephritis ...

    Authors: Marketa Dudkova, Anna Petrackova, Martin Radvansky, Martina Skacelova, Jakub Videman, Jirina Manakova, Veronika Smotkova Kraiczova, Milos Kudelka, Andrea Smrzova, Katerina Langova, Frantisek Mrazek, Eva Kriegova and Pavel Horak
    Citation: Arthritis Research & Therapy 2025 27:41
    Content type: Research Published on:

  21. Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. The anti-inflammatory function of dipeptidyl peptidase-4 (DPP4) inhibitor has been reported in bone metabo...

    Authors: Seung Hoon Lee, Kyu Hoon Lee, Dongju Kim, Chanhyeok Jeon, Min Whangbo, Hye-Ryeong Jo, Jeehee Youn, Chang-Hun Lee, Sung Hoon Choi, Ye-Soo Park, Bora Nam, Sungsin Jo and Tae-Hwan Kim
    Citation: Arthritis Research & Therapy 2025 27:40
    Content type: Research Published on:

  23. Manual muscle testing (MMT8), the current gold standard for assessing muscle function in patients with idiopathic inflammatory myopathies (IIM), has notable limitations. This study had three aims (1) to compar...

    Authors: Felix Kurt Seese, Pia Roscher, Birte Coppers, Julia Greenfield, Manuel Grahammer, Sebastian Kuhn, Latika Gupta, Georg Schett, Johannes Knitza and Anna-Maria Liphardt
    Citation: Arthritis Research & Therapy 2025 27:38
    Content type: Research Published on:

  24. Axial spondyloarthritis (axSpA) is an inflammatory rheumatic disease with challenges in diagnosis and disease activity assessment. While alterations in immunoglobulin G (IgG) N-glycosylation have been observed...

    Authors: Xiaojia Xu, Zhixian Chen, Manshu Song, Zhiduo Hou, Lois Balmer, Chunbin Zhou, Yayi Huang, Haifeng Hou, Wei Wang and Ling Lin
    Citation: Arthritis Research & Therapy 2025 27:37
    Content type: Research Published on:

  25. Mycobacterium avium subspecies Paratuberculosis (MAP) is a bacterium known to cause Johne’s disease in ruminants and has been implicated in several autoimmune diseases. This study aimed to investigate the potenti...

    Authors: Negar Asgari, Ezzat Allah Ghaemi, Samaneh Tavasoli, Mehrdad Aghaei, Hadi Razavi Nikoo and Samin Zamani
    Citation: Arthritis Research & Therapy 2025 27:36
    Content type: Research Published on:

  26. Plasmacytoid dendritic cells (pDCs) play a key role in systemic sclerosis (SSc) pathophysiology. However, despite the recognised importance of metabolic reprogramming for pDC function, their metabolic profile ...

    Authors: Beatriz H. Ferreira, Carolina Mazeda, Eduardo Dourado, João L. Simões, Ana Rita Prata, Rafael J. Argüello, Iola F. Duarte, Philippe Pierre and Catarina R. Almeida
    Citation: Arthritis Research & Therapy 2025 27:35
    Content type: Research Published on:

  27. Rheumatoid arthritis (RA) with anti-citrullinated protein/peptide antibodies (ACPA + RA) demonstrates more significant radiographic damage compared to ACPA-negative RA (ACPA- RA). Chemokine-activated signaling...

    Authors: Xinyu Wang, Lin Sun, Zhuo An, Changhong Li and Jinxia Zhao
    Citation: Arthritis Research & Therapy 2025 27:34
    Content type: Research Published on:

  28. Pulsed electromagnetic field (PEMF) is a non-invasive treatment that utilizes electromagnetic fields to reduce inflammation and promote tissue repair. However, PEMFs’ anti-inflammatory effect on osteoarthritis...

    Authors: Siqi Zhou, Haiyan Wen, Xiongwei He, Xiaotao Han and Haohuan Li
    Citation: Arthritis Research & Therapy 2025 27:33
    Content type: Research Published on:

  29. Several studies have shown that patients with anti-MDA5 antibody-positive dermatomyositis (anti-MDA5 antibody + DM) have an increased risk of developing rapid progression of interstitial lung disease (RPILD), ...

    Authors: Kaikai Zhao, Juan Zhang, Qunyu Kong, Yong Zhang, Cong Li, Kaikai Huo, Na Fan, Wenjing Deng, Jie Shi, Chunya Wang, Xueyi Li, Shuanying Yang and Ping Fang
    Citation: Arthritis Research & Therapy 2025 27:32
    Content type: Research Published on:

  30. Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and a higher incidence of adverse pregnancy outcomes (APOs), and pregnancy can also increase the risk of SLE flares. ...

    Authors: Xueyang Zhang, Lingshan Liu, Shudian Lin, Xinwang Duan, Hui Luo, Yongfu Wang, Zhenbiao Wu, Can Huang, Yin Long, Yixin Cui, Xiaohua Shi, Yijun Song, Juntao Liu, Xiaofeng Zeng, Jiuliang Zhao, Mengtao Li…
    Citation: Arthritis Research & Therapy 2025 27:31
    Content type: Research Published on:

  31. There is a substantial need for ex vivo cartilage damage models to assess new emerging cartilage repair strategies. Ex vivo cartilage explant models have the advantages of achieving standardized and reproducib...

    Authors: Liru Wen, Sibylle Grad, Laura B. Creemers and Martin J. Stoddart
    Citation: Arthritis Research & Therapy 2025 27:30
    Content type: Research Published on:

  33. Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. Current techniques used to d...

    Authors: Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland and Stephen M. Richardson
    Citation: Arthritis Research & Therapy 2025 27:28
    Content type: Research Published on:

  34. Systemic juvenile idiopathic arthritis (sJIA) is the most severe subtype of JIA, with a combination of diverse clinical manifestations and a variable clinical course. A comprehensive understanding of molecular...

    Authors: In-Woon Baek, Jung Woo Rhim, Kyung-Su Park and Ki-Jo Kim
    Citation: Arthritis Research & Therapy 2025 27:27
    Content type: Research Published on:

  35. Dermatomyositis (DM) is an autoimmune disease with a high rate of disability and mortality especially in DM with concurrent interstitial lung disease (DM-ILD). Little is known about inflammatory signature and ...

    Authors: Xinzhi Xu, Tianwen Qiu, Kexin Sun, Xue Han, Junxia Huang, Xiuyuan Wang, Jianchao Ge and Ji Yang
    Citation: Arthritis Research & Therapy 2025 27:26
    Content type: Research Published on:

  36. The aim of this study was to investigate the correlation between age, red cell distribution width (RDW) levels, and 180-day and 1-year mortality in giant cell arteritis (GCA) patients hospitalized or admitted ...

    Authors: Si Chen, Rui Nie, Xiaoran Shen, Yan Wang, Haixia Luan, Xiaoli Zeng, Yanhua Chen and Hui Yuan
    Citation: Arthritis Research & Therapy 2025 27:25
    Content type: Research Published on:

  38. In SELECT-AXIS 2, upadacitinib improved the signs and symptoms of active non-radiographic axial spondyloarthritis (nr-axSpA) through 52 weeks versus placebo and was well tolerated. Here, we evaluated the effic...

    Authors: Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato and Anna Shmagel
    Citation: Arthritis Research & Therapy 2025 27:23
    Content type: Research Published on:

  39. Controlling disease activity and improving physical function would be more difficult in patients with late-onset rheumatoid arthritis (LORA) who have chronic lung disease (CLD) at baseline. Our aim was to eval...

    Authors: Manami Nomura, Takahiko Sugihara, Hiroyuki Baba, Tadashi Hosoya, Mari Kamiya, Tatsuro Ishizaki, Takumi Matsumoto, Kanae Kubo, Fumio Hirano, Masayo Kojima, Nobuyuki Miyasaka, Shinsuke Yasuda and Masayoshi Harigai
    Citation: Arthritis Research & Therapy 2025 27:22
    Content type: Research Published on:

  41. The incorporation of machine learning is becoming more prevalent in the clinical setting. By predicting clinical outcomes, machine learning can provide clinicians with a valuable tool for refining precision me...

    Authors: Rieke Alten, Claire Behar, Pierre Merckaert, Ebenezer Afari, Virginie Vannier-Moreau, Anael Ohayon, Sean E. Connolly, Aurélie Najm, Pierre-Antoine Juge, Gengyuan Liu, Angshu Rai, Yedid Elbez and Karissa Lozenski
    Citation: Arthritis Research & Therapy 2025 27:20
    Content type: Research Published on:

  42. To evaluate the ability to discriminate giant cell arteritis (GCA) from Takayasu arteritis (TAK) according to the modified 2022 American College of Rheumatology/European Alliance of Associations for Rheumatolo...

    Authors: Takahiko Sugihara, Masayoshi Harigai, Haruhito A. Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Jun Ishizaki, Yoshiko Watanabe, Hiroaki Dobashi, Yoshinori Komagata, Naoto Tamura and Yoshikazu Nakaoka
    Citation: Arthritis Research & Therapy 2025 27:19
    Content type: Research Published on:

  43. Efficacy of tumour necrosis factor inhibitors (TNFi) for peripheral arthritis in patients with psoriatic arthritis (PsA) has been established in randomized clinical trials that have used improvement in summate...

    Authors: Adrian Ciurea, Seraphina Kissling, Andrea Götschi, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Bálint Tamási, Burkhard Möller, Michael J. Nissen, Bente Glintborg, Anne Gitte Loft, Almut Scherer, René Bräm, Karel Pavelka, Jakub Závada, Joao Madruga Dias, Paula Valente…
    Citation: Arthritis Research & Therapy 2025 27:18
    Content type: Research Published on:

  44. Optical spectral transmission (OST) is a modern diagnostic method capable of quantifying inflammation in the finger and wrist joints of arthritis patients by assessing the blood-specific absorption of light tr...

    Authors: Konstantinos Triantafyllias, Mohammed Alhaddad, Andreas Schwarting, Veronika Balaklytska and Xenofon Baraliakos
    Citation: Arthritis Research & Therapy 2025 27:17
    Content type: Research Published on:

  45. Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes.

    Authors: Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin and Jian Zuo
    Citation: Arthritis Research & Therapy 2025 27:16
    Content type: Research Published on:

  46. To explore IL11 co-expression profiles in our previously reported RNA-sequencing dataset of OA articular cartilage, in interaction with IL6, and to investigate the effects of hrIL11 administration as potential th...

    Authors: Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad and Ingrid Meulenbelt
    Citation: Arthritis Research & Therapy 2025 27:15
    Content type: Research Published on:

  47. To investigate cancer incidence and the potential influence of immunosuppressive agents in Korean systemic lupus erythematosus (SLE) patients.

    Authors: Soo-Kyung Cho, Jung-Yong Han, Yena Jeon, Seung-Hun You, Sun-Young Jung, Eun Jin Jang and Yoon-Kyoung Sung
    Citation: Arthritis Research & Therapy 2025 27:14
    Content type: Research Published on:

  48. Describe patterns of pharmacotherapy and psychological treatment and evaluate receipt of minimally adequate treatment for incident depression and anxiety in individuals with inflammatory arthritis (IA).

    Authors: Alyssa Howren, Eric C. Sayre, J. Antonio Avina-Zubieta, Joseph H. Puyat, Deborah Da Costa, Hui Xie, Eileen Davidson, Amit Gupta and Mary A. De Vera
    Citation: Arthritis Research & Therapy 2025 27:13
    Content type: Research Published on:

  49. Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joints. Despite the availability of various targeted drugs for RA, these treatments are limi...

    Authors: Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin and Qibing Xie
    Citation: Arthritis Research & Therapy 2025 27:12
    Content type: Research Published on:

  50. Advances in treatment have swiftly alleviated systemic inflammation of Takayasu’s arteritis (TAK), while subclinical vascular inflammation and the ensuing arterial remodeling continue to present unresolved cha...

    Authors: Shuning Guo, Jiehan Li, Shurui Pang, Jing Li and Xinping Tian
    Citation: Arthritis Research & Therapy 2025 27:11
    Content type: Research Published on:
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Arthritis Research & Therapy

ISSN: 1478-6362

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