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  1. Currently, the pathophysiology of new bone formation in radiographic axial spondyloarthritis (r-axSpA) remains unclear. Cellular elements and their secreted bone turnover markers might be one of the underlying...

    Authors: Xuegang Li, Haijian Jiang, Xu Wang and Shuping Zhong
    Citation: Arthritis Research & Therapy 2025 27:10
  2. To explore the role of newly emerging autoantibodies (AAbs) - peptidyl-arginine deiminase 4 (aPAD4), carbamylated proteins (aCarP), and anti-RA33 (aRA33) - alongside the traditionally assessed rheumatoid facto...

    Authors: Alberto Floris, Maria Maddalena Angioni, Mattia Fadda, Micaela Rita Naitza, Mattia Congia, Elisabetta Chessa, Matteo Piga and Alberto Cauli
    Citation: Arthritis Research & Therapy 2025 27:9
  3. Axial spondyloarthritis (SpA) leads to structural bone lesions in every part of the vertebral column. These lesions are only partially visualized on conventional radiographs, omitting posterior parts of the ve...

    Authors: Andreas Haidmayer, Gabriel Adelsmayr, Christopher Spreizer, Eva Valentina Klocker, Franz Quehenberger, Michael Fuchsjaeger, Jens Thiel and Josef Hermann
    Citation: Arthritis Research & Therapy 2025 27:8
  4. The objective of this study was to investigate the therapeutic effectiveness and safety profile of Eltrombopag, a thrombopoietin receptor agonist, as prolonged therapy in refractory CTD-ITP patients.

    Authors: Siying Deng, Bei Wang, Ziwei Hu, Shaozhe Cai and Lingli Dong
    Citation: Arthritis Research & Therapy 2025 27:7
  5. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, tissue damage, and fibrosis, significantly affecting the quality of life. While there are currently some effective...

    Authors: Zhongsheng Zhou, Shuhui Wu, Yang Li, Pu Shao and Jinlan Jiang
    Citation: Arthritis Research & Therapy 2025 27:6
  6. To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time si...

    Authors: Tatiana Cobo-Ibáñez, Ivan Castellví, Ana Pros, Marta Domínguez-Álvaro, Laura Nuño-Nuño, Julia Martínez-Barrio, Vega Jovaní, Fredeswinda Romero-Bueno, Esther Ruiz-Lucea, Eva Tomero, Ernesto Trallero-Araguás, Javier Narváez, Jordi Camins-Fàbregas, Alberto Ruiz-Román, Jesús Loarce-Martos, Susana Holgado-Pérez…
    Citation: Arthritis Research & Therapy 2025 27:5
  7. To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality.

    Authors: Juan Molina-Collada, Marta Domínguez-Álvaro, Rafael B. Melero-González, Eugenio de Miguel, Maite Silva-Díaz, Jesús Alejandro Valero Jaimes, Ismael González, Julio Sánchez Martín, Javier Narváez, Joan Calvet, Ivette Casafont-Solé, Jose A Román Ivorra, Selene Labrada Arrabal, Margarida Vasques Rocha, Carlota L Iñiguez, María Sagrario Bustabad Reyes…
    Citation: Arthritis Research & Therapy 2025 27:4
  8. Severe gastrointestinal lesions are associated with a poor prognosis in eosinophilic granulomatosis with polyangiitis (EGPA). The goal of this study was to develop an effective predictive model for gastrointes...

    Authors: Suying Liu, Yunjiao Yang, Linna Han, Chengmei He, Mengtao Li, Xinping Tian, Juan Meng, Li Wang and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2025 27:3
  9. There is still a significant proportion of patients with rheumatoid arthritis (RA) in whom multiple therapeutic lines are ineffective. These cases are defined by the EULAR criteria as Difficult-to-Treat RA (D2...

    Authors: Nicoletta Luciano, Elisa Barone, Enrico Brunetta, Alessio D’Isanto, Maria De Santis, Angela Ceribelli, Marta Caprioli, Giacomo M. Guidelli, Daniela Renna and Carlo Selmi
    Citation: Arthritis Research & Therapy 2025 27:2
  10. Primary Sjogren’s syndrome (pSS) and autoimmune thyroiditis (AIT) share overlapping genetic and immunological profiles. This retrospective study evaluates the efficacy of machine learning algorithms, with a fo...

    Authors: Jia-yun Wu, Jing-yu Zhang, Wen-qi Xia, Yue-ning Kang, Ru-yi Liao, Yu-ling Chen, Xiao-min Li, Ya Wen, Fan-xuan Meng, Li-ling Xu, Sheng-hui Wen, Hui-fen Liu, Yuan-qing Li, Jie-ruo Gu, Qing Lv and Yong Ren
    Citation: Arthritis Research & Therapy 2025 27:1
  11. To investigate differences in arterial involvement patterns on 18F-FDG PET-CT between predominant cranial and isolated extracranial phenotypes of giant cell arteritis (GCA).

    Authors: Javier Narvaez, Paola Vidal-Montal, Iván Sánchez-Rodríguez, Aida Sabaté-Llobera, Montserrat Cortés-Romera, Judith Palacios-Olid, Pol Maymó-Paituvi and Joan Miquel Nolla
    Citation: Arthritis Research & Therapy 2024 26:230
  12. Thrombocytopenia (TP) is a hematological manifestation of systemic lupus erythematosus (SLE) and is associated with unfavorable prognostic outcomes. This study aimed to develop a risk prediction model for new-...

    Authors: Yupei Zhang, Nan Jiang, Xinwang Duan, Jian Xu, Lijun Wu, Wei Wei, Weiguo Xiao, Li Luo, Zhenyu Jiang, Yanhong Wang, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2024 26:229
  13. High body mass index (BMI) has been shown to have an association with chronic widespread pain (CWP), both in Rheumatoid arthritis (RA) and in other pain conditions such as fibromyalgia. Research on the adipose...

    Authors: M. Aronsson, S. Bergman, E. Lindqvist and M. L. E. Andersson
    Citation: Arthritis Research & Therapy 2024 26:228
  14. Rheumatoid arthritis (RA) is a chronic inflammatory condition that, despite available approaches to manage the disease, lacks an efficient treatment and timely diagnosis. Using the most advanced omics techniqu...

    Authors: Prachi Agnihotri, Mohd Saquib, Lovely Joshi, Swati Malik, Debolina Chakraborty, Ashish Sarkar, Uma Kumar and Sagarika Biswas
    Citation: Arthritis Research & Therapy 2024 26:227
  15. Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disorder. Diet is recognized as a modifiable factor that may influence inflammation and potentially accelerate RA progression. Neverthel...

    Authors: Penghe Wang, Dongni Wang, Jiayu Sui, Shuang Liu, Yingjing Kong, Hongwei Lei and Maomao Zhang
    Citation: Arthritis Research & Therapy 2024 26:226
  16. To assess immunogenicity and safety in patients with active rheumatoid arthritis (RA) transitioning from rituximab [US-licensed rituximab: Reference Product (RP); EU-approved rituximab: Reference Medicinal Pro...

    Authors: Narendra Maharaj, Dharma Rao Uppada, Naveen Reddy, Pramod Reddy, Anastas Batalov, Delina lvanova, Nedyalka Staykova, Asta Baranauskaite and Laila Amirali Hassan
    Citation: Arthritis Research & Therapy 2024 26:225
  17. Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to O...

    Authors: Terese Geraghty, Shingo Ishihara, Alia M. Obeidat, Natalie S. Adamczyk, Rahel S. Hunter, Jun Li, Lai Wang, Hoomin Lee, Frank C. Ko, Anne-Marie Malfait and Rachel E. Miller
    Citation: Arthritis Research & Therapy 2024 26:224
  18. Accumulated evidence supports the tendency of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis(AAV) to coexist with atherosclerosis (AS). However, the common etiology of these two diseases rema...

    Authors: Xun Hu, Inmaculada Xu Lou and Qilan Chen
    Citation: Arthritis Research & Therapy 2024 26:223
  19. Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of ...

    Authors: Hongshuai Zhao, Zaichuan Lin, Peiwen Zhang, Jiayue Rao, Shumin Xu, Qing Luo and Junming Li
    Citation: Arthritis Research & Therapy 2024 26:222
  20. This study investigated poor prognostic factors for the relapse of interstitial lung disease (ILD) in patients with microscopic polyangiitis (MPA) after remission induction therapy.

    Authors: Shogo Matsuda, Takuya Kotani, Ayana Okazaki, Daisuke Nishioka, Yuichi Masuda, Mayu Shiomi, Ryu Watanabe, Tomoki Taniguchi, Atsushi Manabe, Keiichiro Kadoba, Tsuneyasu Yoshida, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto and Tohru Takeuchi
    Citation: Arthritis Research & Therapy 2024 26:221
  21. To investigate the levels of plasma neutrophil extracellular traps (NETs) and free thiols, the latter reflecting systemic oxidative stress (OS), and to explore the relationship between NETs and OS in quiescent...

    Authors: Lu Liu, Karina de Leeuw, Harry van Goor, Berber Doornbos-van der Meer, Suzanne Arends and Johanna Westra
    Citation: Arthritis Research & Therapy 2024 26:220
  22. This study aimed to assess the quantitative uptake of 18F-FDG PET-CT in the lungs of patients with early severe diffuse cutaneous systemic sclerosis (SSc) with and without interstitial lung disease (ILD), compare...

    Authors: Bo Broens, Esther J. Nossent, Lilian J. Meijboom, Gerben J. C. Zwezerijnen, Julia Spierings, Jeska K. de Vries-Bouwstra, Jacob M. van Laar, Conny J. van der Laken and Alexandre E. Voskuyl
    Citation: Arthritis Research & Therapy 2024 26:219
  23. Data on treatment switching directly from tumor necrosis factor inhibitors to tofacitinib in psoriatic arthritis (PsA) are limited. This post hoc analysis assessed efficacy and safety outcomes in patients with...

    Authors: Dafna D. Gladman, Peter Nash, Philip J. Mease, Oliver FitzGerald, Stephanie Duench, Mary Jane Cadatal and Karim R. Masri
    Citation: Arthritis Research & Therapy 2024 26:218
  24. Minor salivary gland (MSG) biopsy is a critical but invasive method for the classification of primary Sjögren’s disease (pSjD). Here we aimed to identify salivary proteins as potential biomarkers and to establ...

    Authors: Xinwei Zhang, Zhangdi Liao, Yangchun Chen, Huiqin Lu, Aodi Wang, Yingying Shi, Qi Zhang, Ying Wang, Yan Li, Jingying Lan, Chubing Chen, Chaoqiong Deng, Wuwei Zhuang, Lingyu Liu, Hongyan Qian, Shiju Chen…
    Citation: Arthritis Research & Therapy 2024 26:217
  25. In an age where there is a remarkable upsurge in developing precision medicines, antibody-drug conjugates (ADCs) have emerged as a progressive therapeutic strategy. ADCs typically consist of monoclonal antibod...

    Authors: Tanu Dixit, Anuradha Vaidya and Selvan Ravindran
    Citation: Arthritis Research & Therapy 2024 26:216
  26. Limb-girdle muscular dystrophy (LGMD) is usually confused with idiopathic inflammatory myopathy (IIM) in clinical practice. Our study aimed to establish convenient and reliable diagnostic models for distinguis...

    Authors: Guangyu Wang, Lijun Fu, Lining Zhang, Kai Shao, Ying Hou, Tingjun Dai, Pengfei Lin, Chuanzhu Yan and Bing Zhao
    Citation: Arthritis Research & Therapy 2024 26:215
  27. Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial linin...

    Authors: Khaled A. Elsaid, Ling X. Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Tannin A. Schmidt and Gregory D. Jay
    Citation: Arthritis Research & Therapy 2024 26:214
  28. To use routine demographic and clinical data to develop an interpretable individual-level machine learning (ML) model to diagnose knee osteoarthritis (KOA) and to identify highly ranked features.

    Authors: Zijuan Fan, Wenzhu Song, Yan Ke, Ligan Jia, Songyan Li, Jiao Jiao Li, Yuqing Zhang, Jianhao Lin and Bin Wang
    Citation: Arthritis Research & Therapy 2024 26:213
  29. In the murine K/BxN serum transfer rheumatoid arthritis (RA) model, tactile allodynia persists after resolution of inflammation in male and partially in female wild type (WT) mice, which is absent in Toll-like...

    Authors: Gilson Goncalves dos Santos, Juan Miguel Jiménez-Andrade, Enriqueta Muñoz-Islas, Mariana E. Candanedo-Quiroz, Andrea Gonzalez Cardenas, Bronwen Drummond, Peter Pham, Gwendalynn Stilson, Chao-Chin Hsu, Lauriane Delay, Juliana M. Navia-Pelaez, Julia Paes Lemes, Yury I. Miller, Tony L. Yaksh and Maripat Corr
    Citation: Arthritis Research & Therapy 2024 26:212
  30. The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the...

    Authors: Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt and Wolfgang Merkt
    Citation: Arthritis Research & Therapy 2024 26:211
  31. Clonal T cell populations are frequently detected in patients with rheumatic diseases. The relevance of this finding is often uncertain, as the clinical spectrum can range from being asymptomatic to T cell leu...

    Authors: Michael Gernert, Tobias Müller, Lukas Schweiker, Marc Schmalzing, Matthias Fröhlich, Lea-Kristin Nagler, Patrick-Pascal Strunz, Hannah Labinsky and Eva Christina Schwaneck
    Citation: Arthritis Research & Therapy 2024 26:210
  32. To investigate the association between the development of incident interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) and the disease activity of RA with its various components, especia...

    Authors: Ronja Ramien, Tatjana Rudi, Rieke Alten, Andreas Krause, Matthias Schneider, Martin Schaefer, Anja Strangfeld and Yvette Meissner
    Citation: Arthritis Research & Therapy 2024 26:209
  33. Spondyloarthritides (SpAs) are a group of common rheumatic diseases that often cause limited mobility and lower back pain. Physiotherapy is an integral part of treatment, but access to physiotherapy limits tre...

    Authors: Paloma Palm von Alten Blaskowitz, Anna-Maria Liphardt, Claudia Bouzas, Birte Coppers, Pascal Petit, Nicolas Vuillerme, Vanessa Bundle, Sebastian Rudolf, Johannes Knitza, Maria Gabriella Raimondo, Hannah Labinsky, Lukas Hatscher, Andreas Wirsching, Daniela Bohr, Elizabeth Araujo, Andreas Ramming…
    Citation: Arthritis Research & Therapy 2024 26:208
  34. This study investigates the causal role of metabolites mediating immune cells in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) through a Mendelian randomization (MR) study.

    Authors: Jinpeng Wei, Jian Li, Tianyang Li, Tao Xu, Yingchi Zhang, Shuhan Yang, Hua Wu and Haihu Hao
    Citation: Arthritis Research & Therapy 2024 26:207
  35. Authors: Antonella Notarnicola, Charlotta Preger, Susanna L. Lundström, Nuria Renard, Edvard Wigren, Eveline Van Gompel, Angeles S. Galindo-Feria, Helena Persson, Maryam Fathi, Johan Grunewald, Per-Johan Jakobsson, Susanne Gräslund, Ingrid E. Lundberg and Cátia Fernandes-Cerqueira
    Citation: Arthritis Research & Therapy 2024 26:206

    The original article was published in Arthritis Research & Therapy 2022 24:62

  36. Gout is caused by the response of the innate immune system to monosodium urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a locus encompassing IL1RN-IL1F10. Colocalisation an...

    Authors: Orsolya I. Gaal, Megan Leask, Valentin Nica, Georgiana Cabău, Medeea Badii, Ioana Hotea, Dennis M de Graaf, Zhenhua Zhang, Yang Li, Cristina Pamfil, Simona Rednic, Tony R. Merriman, Tania O. Crișan and Leo A.B. Joosten
    Citation: Arthritis Research & Therapy 2024 26:205
  37. Previously, we reported that serum Semaphorin 5 A (Sema5A) levels were increased in systemic lupus erythematosus (SLE) patients compared with healthy controls (HC), and elevated Sema5A correlated with disease ...

    Authors: Xin Chen, Lingjiang Zhu, Jieying Xu, Qi Cheng, Yuanji Dong, Yifan Xie, Li Hua and Yan Du
    Citation: Arthritis Research & Therapy 2024 26:204
  38. Knee osteoarthritis (KOA) is characterized by mitochondrial damage and increased inflammation. Circulating cell-free mitochondrial DNA (ccf-mtDNA), which originates from damaged mitochondria, is an endogenous ...

    Authors: Yan-lin Wu, Shao-gui Wan, Yi Long, Hua Ye, Jia-ming Yang, Yun Luo, Yan-biao Zhong, Li Xiao, Hai-yan Chen and Mao-yuan Wang
    Citation: Arthritis Research & Therapy 2024 26:202
  39. Systemic lupus erythematosus (SLE) is an incurable chronic autoimmune disease of unknown etiology. Therefore, the development of new treatments is urgently needed. This study aimed to investigate the therapeut...

    Authors: Eun Wha Choi, Il Seob Shin, I-Rang Lim, Jihye Lee, Bongkum Choi and Sungjoo Kim
    Citation: Arthritis Research & Therapy 2024 26:201
  40. Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and significant social and economic burden. Women have a higher risk of OA, more severe clinical s...

    Authors: Chongyang Feng, Lin Liu, Jinxue Zhang, Linxiao Wang, Ke Lv, Hongbo Li and Yong Ding
    Citation: Arthritis Research & Therapy 2024 26:200
  41. Osteoarthritis (OA) is a degenerative joint disease caused by the breakdown of joint cartilage and adjacent bone. Joint injury, being overweight, differences in leg length, high levels of joint stress, abnorma...

    Authors: Jeonghyeon Moon, Keun-Hyung Cho, JooYeon Jhun, JeongWon Choi, Hyun-Sik Na, Jeong Su Lee, Seung Yoon Lee, Jun-Ki Min, Anan Shetty, Sung-Hwan Park, Seok Jung Kim and Mi-La Cho
    Citation: Arthritis Research & Therapy 2024 26:199
  42. Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in patients undergoing immunosuppressive therapy, such as glucocorticoid (GC) medication, for systemic autoimmune diseases like systemic lupus ...

    Authors: Takahisa Onishi, Ken-ei Sada, Keigo Hayashi, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato, Michio Fujiwara, Nobuyuki Yajima, Takashi Kida, Yusuke Matsuo, Keisuke Nishimura and Takashi Yamane
    Citation: Arthritis Research & Therapy 2024 26:198
  43. The efficacy and safety of upadacitinib in patients with ankylosing spondylitis (AS) and inadequate response/intolerance to biologic disease-modifying antirheumatic drugs (bDMARD-IR) were evaluated through 1 y...

    Authors: Xenofon Baraliakos, Désirée van der Heijde, Joachim Sieper, Robert Davies Inman, Hideto Kameda, Walter Peter Maksymowych, Ivan Lagunes-Galindo, Xianwei Bu, Peter Wung, Koji Kato, Anna Shmagel and Atul Deodhar
    Citation: Arthritis Research & Therapy 2024 26:197
  44. Serum protein abundance was assessed in adult and juvenile dermatomyositis (DM and JDM) patients to determine differentially regulated proteins, altered pathways, and candidate disease activity biomarkers.

    Authors: A. Clare Sparling, James M. Ward, Kakali Sarkar, Adam Schiffenbauer, Payam Noroozi Farhadi, Michael A. Smith, Saifur Rahman, Kamelia Zerrouki, Frederick W. Miller, Jian-Liang Li, Kerry A. Casey and Lisa G. Rider
    Citation: Arthritis Research & Therapy 2024 26:196
  45. Patient trust plays a central role in the patient-physician relationship. This study aimed to determine whether the number of outpatient visits with a covering rheumatologist is associated with patient trust i...

    Authors: Yu Katayama, Yoshia Miyawaki, Kenta Shidahara, Shoichi Nawachi, Yosuke Asano, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano-Narazaki, Yoshinori Matsumoto, Nao Oguro, Nobuyuki Yajima, Yuichi Ishikawa, Natsuki Sakurai, Chiharu Hidekawa, Ryusuke Yoshimi, Shigeru Ohno…
    Citation: Arthritis Research & Therapy 2024 26:195
  46. Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patients. This study aimed to investigate the resting state (RS) functional alternations of S...

    Authors: Xinyu Tong, Huilin He, Shihan Xu, Rui Shen, Zihan Ning, Xiaofeng Zeng, Qian Wang, Dong Xu, Zuo-Xiang He and Xihai Zhao
    Citation: Arthritis Research & Therapy 2024 26:194
  47. Our objective was to ascertain the most recent prevalence and trends of hyperuricemia among adolescents, stratified by sex and race/ethnicity subgroups, as well as to investigate potential risk factors associa...

    Authors: Kaifeng Guo, Yali Han, Shuang Liu, Hang Sun, Xiaojing Lin, Shaoling Yang, Yining Gao and Haibing Chen
    Citation: Arthritis Research & Therapy 2024 26:193
  48. To investigate the frequency of difficult-to-treat (D2T) rheumatoid arthritis (RA) in patients early escalated to biologic/targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs) after failure o...

    Authors: Bernardo D’Onofrio, Ludovico De Stefano, Emanuele Bozzalla Cassione, Valentina Morandi, Francesca Cuzzocrea, Garifallia Sakellariou, Antonio Manzo, Carlomaurizio Montecucco and Serena Bugatti
    Citation: Arthritis Research & Therapy 2024 26:192
  49. Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to investigate SLE-pathogenic gut microbes and their potential mechanisms.

    Authors: Lian Gui, Xiaoyu Zuo, Junmei Feng, Mingbang Wang, Zena Chen, Yuhan Sun, Jun Qi, Zhuanggui Chen, Janak L. Pathak, Yanli Zhang, Chunping Cui, Pingping Zhang, Xinghua Guo, Qing Lv, Xi Zhang, Yan Zhang…
    Citation: Arthritis Research & Therapy 2024 26:191

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  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

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    Submission to first editorial decision (median days): 11
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